Ignite Creation Date:
2024-07-17 @ 11:45 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06480591
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-28
First Post:
2024-06-07
Brief Title:
Evaluation of the Pathobiology of CALR-mutated MPN Cells
Sponsor:
Wake Forest University Health Sciences
Organization:
Wake Forest University Health Sciences
Study Overview
Official Title:
Evaluation of the Pathobiology of CALR-mutated MPN Cells
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to understand why there is a greater risk of thrombosis in patients who have the JAK2 mutation as compared to those with CALR mutations
Detailed Description:
This biospecimen study is designed to evaluate the expression levels of TLR 2 and TLR 4 on mononuclear cells in CALR mutation positive MPN participants and compare to JAK2 V617F mutation positive MPN patients and healthy controls Patients who have MPN with the CALR mutation positive will be approached for interest in participating in this study A research blood collection will occur at any time during the participants cancer trajectory after enrollment during a standard of care blood draw The participants demographics MPN subtype CALR mutation status history of thrombosisother medical history and current concomitant medications will be collected once Clinical data will be collected including results from the CBC with differential complete metabolic panel if available and PTPTTINR if available drawn closest to the research blood collection This study will initially open as a single center study at AHWFBCCC
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| LCI-HEM-MPN-CALR-001 | OTHER | None | None |