Ignite Creation Date:
2024-07-17 @ 11:44 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06466980
Status:
RECRUITING
Last Update Posted:
2024-06-24
First Post:
2024-06-14
Brief Title:
Study of Ventilator Associated Event During Intensive Care After Resuscitated Cardiac Arrest
Sponsor:
Centre Hospitalier Sud Francilien
Organization:
Centre Hospitalier Sud Francilien
Study Overview
Official Title:
Study of Ventilator Associated Event During Intensive Care After Resuscitated Cardiac Arrest
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
VAE-ACR
Brief Summary:
The aim is to describe the incidence characteristics risk factors and outcome of complications acquired under mechanical ventilation called ventilator-associated events according to the new CDC criteria in a population of patients admitted in intensive care unit after cardiac arrest
Detailed Description:
Cardiac arrest CA survivors are frequently admitted to intensive care units Despite improvements in management techniques the prognosis of these patients remains poor with mortality exceeding 90 for out-of-hospital CA and around 80 for in-hospital CA along with a high risk of severe neurological issue
The management of these patients in intensive care requires the use of invasive mechanical ventilation Complications occurring under mechanical ventilation have been the subject of many researches Early bacterial pneumonia or ventilator-acquired pneumonia appears as the primary cause of respiratory worsening and several studies have already focused on their incidence and prevention However studies on the benefits of antibiotic therapy or antibiotic prophylaxis for early pulmonary infections are of tricky analysis particularly when they do not consider respiratory condition or mortality for their primary outcome measure
A new definition of complications associated with mechanical ventilation VAEs has been established by the Centers for Disease Control and Prevention CDC since 2013 It offers a more relevant tool for monitoring the impact of preventive measures on morbidity and mortality with a more objective definition that goes beyond just tracking ventilator-associated pneumonia
Several studies have since analyzed the incidence and impact of VAEs on cohorts of intensive care patients confirming the association between VAEs and morbidity and mortality However to our knowledge none have targeted a population of cardiac arrest survivors
The management of these patients in intensive care requires the use of invasive mechanical ventilation Complications occurring under mechanical ventilation have been the subject of many researches Early bacterial pneumonia or ventilator-acquired pneumonia appears as the primary cause of respiratory worsening and several studies have already focused on their incidence and prevention However studies on the benefits of antibiotic therapy or antibiotic prophylaxis for early pulmonary infections are of tricky analysis particularly when they do not consider respiratory condition or mortality for their primary outcome measure
A new definition of complications associated with mechanical ventilation VAEs has been established by the Centers for Disease Control and Prevention CDC since 2013 It offers a more relevant tool for monitoring the impact of preventive measures on morbidity and mortality with a more objective definition that goes beyond just tracking ventilator-associated pneumonia
Several studies have since analyzed the incidence and impact of VAEs on cohorts of intensive care patients confirming the association between VAEs and morbidity and mortality However to our knowledge none have targeted a population of cardiac arrest survivors
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None