Ignite Creation Date:
2024-07-17 @ 11:44 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06466083
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-20
First Post:
2024-05-29
Brief Title:
Correlation Analysis of POD and PND in Elderly Spinal Surgery Patients Based on Rs-fMRI
Sponsor:
Xuanwu Hospital Beijing
Organization:
Xuanwu Hospital Beijing
Study Overview
Official Title:
Correlation Analysis of Postoperative Delirium and Postoperative Neurocognitive Disorder in Elderly Spinal Surgery Patients Based on Resting State Functional Magnetic Resonance Imaging
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is a prospective cohort study to investigate the differences in resting-state functional magnetic resonance imaging fMRI between elderly spinal surgery patients with postoperative delirium POD who either develop or do not develop long-term postoperative neurocognitive disorders pNCD
Detailed Description:
To investigate the differences in resting-state functional magnetic resonance imaging fMRI between elderly spinal surgery patients with postoperative delirium POD who either develop or do not develop long-term postoperative neurocognitive disorders pNCD
Neurocognitive function of the study participants was assessed within one week before surgery using the Montreal Cognitive Assessment MoCA Perform baseline MRI scan before surgery Under routine anesthetic management of the Department of Anesthesiology and Surgical Operations at Xuanwu Hospital endotracheal intubation general anesthesia was performed Within 7 days post-surgery delirium assessment was conducted using the Confusion Assessment Method CAM classifying patients into POD and non-POD groups Neurocognitive function assessments were conducted long-term after surgery for the POD group to determine the presence of pNCD further dividing the POD group into pNCD and non-pNCD subgroups followed by fMRI scanningBy comparing the patterns and intensities of brain functional connectivity between the pNCD and non-pNCD subgroups a differential analysis was conducted on the effective connectivity and information flow of functional networks exploring the state of the brain functional network during the process of POD and pNCD
Neurocognitive function of the study participants was assessed within one week before surgery using the Montreal Cognitive Assessment MoCA Perform baseline MRI scan before surgery Under routine anesthetic management of the Department of Anesthesiology and Surgical Operations at Xuanwu Hospital endotracheal intubation general anesthesia was performed Within 7 days post-surgery delirium assessment was conducted using the Confusion Assessment Method CAM classifying patients into POD and non-POD groups Neurocognitive function assessments were conducted long-term after surgery for the POD group to determine the presence of pNCD further dividing the POD group into pNCD and non-pNCD subgroups followed by fMRI scanningBy comparing the patterns and intensities of brain functional connectivity between the pNCD and non-pNCD subgroups a differential analysis was conducted on the effective connectivity and information flow of functional networks exploring the state of the brain functional network during the process of POD and pNCD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None