Ignite Creation Date:
2024-07-17 @ 11:39 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06463366
Status:
RECRUITING
Last Update Posted:
2024-06-17
First Post:
2024-04-16
Brief Title:
Multi-parametric Magnetic Resonance Imaging for the Precise Diagnosis and Quantitative Study of Liver Steatosis Inflammation and Fibrosis in Chronic Liver Disease
Sponsor:
Shengjing Hospital
Organization:
Shengjing Hospital
Study Overview
Official Title:
Multi-parametric Magnetic Resonance Imaging for the Precise Diagnosis and Quantitative Study of Liver Steatosis Inflammation and Fibrosis in Chronic Liver Disease
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To construct a novel non-invasive accurate and convenient method to achieve the degree of liver damage is an important general problem in the management of patients with chronic liver disease The investigators would like to develop non invasive advanced Magnetic Resonance Imaging MRI techniques MR elastography MRI-PDFF to assess the degree of liver damage in patients with chronic liver disease These techniques could reach high diagnostic performance for detection of liver fibrosis inflammation and liver fat content and could decrease the number of liver biopsies which have risks and sample only a small portion of the liver
Detailed Description:
Patients with chronic hepatitis have increased risks of liver damage including fibrosis and cirrhosis which may eventually lead to hepatocellular carcinoma and end-stage liver disease requiring liver transplantation These diseases arewill be the source of enormous health care costs and morbiditymortality in the China
Most hepatologists still rely on liver biopsy findings in patients newly diagnosed with chronic hepatitis which enables the assessment of liver damage fibrosis and inflammation Liver biopsy has limitations including cost invasiveness poor patient acceptance limited sampling inter-observer variability and is difficult to repeat
Non invasive tests to capture the extent of liver damage at a larger scale are urgently needed These will gain more acceptance among patients and hepatologists
In this proposal the investigators would like to test and validate non invasive MRI methods based on advanced MR elastography and MRI-PDFF techniques for the detection of fibrosis cirrhosis and liver fat content in patients with chronic hepatitis In order to improve the diagnostic performance of MRI the investigators would like to build and validate a predictive model based on advanced functional MRI metrics storage modulus loss modulus and damping ratio DR by follow up every 6 month If validated this novel non invasive algorithm will not only decreases the number of liver biopsies but also enable earlier diagnosis of liver fibrosis when antiviral treatment is more effective and enable a comprehensive evaluation of the liver to assess for cirrhosis portal hypertension and hepatocellular cancer
This study is aimed to evaluate whether the change of liver stiffness assessed by MRE can predict treatment effectiveness in chronic liver disease treatment by follow up every 6 month
Most hepatologists still rely on liver biopsy findings in patients newly diagnosed with chronic hepatitis which enables the assessment of liver damage fibrosis and inflammation Liver biopsy has limitations including cost invasiveness poor patient acceptance limited sampling inter-observer variability and is difficult to repeat
Non invasive tests to capture the extent of liver damage at a larger scale are urgently needed These will gain more acceptance among patients and hepatologists
In this proposal the investigators would like to test and validate non invasive MRI methods based on advanced MR elastography and MRI-PDFF techniques for the detection of fibrosis cirrhosis and liver fat content in patients with chronic hepatitis In order to improve the diagnostic performance of MRI the investigators would like to build and validate a predictive model based on advanced functional MRI metrics storage modulus loss modulus and damping ratio DR by follow up every 6 month If validated this novel non invasive algorithm will not only decreases the number of liver biopsies but also enable earlier diagnosis of liver fibrosis when antiviral treatment is more effective and enable a comprehensive evaluation of the liver to assess for cirrhosis portal hypertension and hepatocellular cancer
This study is aimed to evaluate whether the change of liver stiffness assessed by MRE can predict treatment effectiveness in chronic liver disease treatment by follow up every 6 month
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None