Ignite Creation Date:
2024-07-17 @ 11:39 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06475573
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-06-26
First Post:
2024-06-21
Brief Title:
Fermented Dietary Fiber and Probiotics on OverweightObese Patients
Sponsor:
Second Affiliated Hospital School of Medicine Zhejiang University
Organization:
Second Affiliated Hospital School of Medicine Zhejiang University
Study Overview
Official Title:
Effect of Fermented Dietary Fiber and Probiotics on the Intervention of OverweightObese Patients With Impaired Glucose Regulation
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to investigate the efficacy of fermented dietary fiber and probiotics in improving glycemic control and associated metabolic parameters in overweightobese IGR patients The ultimate goal is to establish a clinically applicable nutrition intervention strategy for glucose tolerance impaired individuals
Detailed Description:
Impaired glucose regulation IGR encompassing impaired fasting glucose IFG andor impaired glucose tolerance IGT represents a crucial stage in the progression to type 2 diabetes Characterized by a state of compensatory glucose dysmetabolism IGR is closely linked to overweightobesity and can be reversed through lifestyle interventions Timely intervention during this stage can promote weight loss delay or prevent the onset and development of diabetes and reduce the risk of cardiovascular diseases chronic kidney disease and all-cause mortality
Current treatment approaches for overweightobese IGR patients include dietary and physical activity modifications pharmacotherapy and bariatric surgery However individual responses to these interventions vary considerably Dietary fiber essential for maintaining normal gastrointestinal function has been associated with an increased risk of various diseases including colorectal cancer cardiovascular diseases obesity metabolic syndrome and type 2 diabetes when consumed in inadequate amounts Conversely the gut microbiota plays a pivotal role in diabetes development and progression Probiotics potentially through the stimulation of short-chain fatty acid production and the induction of gut hormone secretion that influences blood glucose levels may exert beneficial effects by enhancing immune modulation increasing anti-inflammatory cytokine production reducing intestinal permeability and mitigating oxidative stress
Therefore this study aims to investigate the efficacy of fermented dietary fiber and probiotics in improving glycemic control and associated metabolic parameters in overweightobese IGR patients The ultimate goal is to establish a clinically applicable nutrition intervention strategy for glucose tolerance impaired individuals
Current treatment approaches for overweightobese IGR patients include dietary and physical activity modifications pharmacotherapy and bariatric surgery However individual responses to these interventions vary considerably Dietary fiber essential for maintaining normal gastrointestinal function has been associated with an increased risk of various diseases including colorectal cancer cardiovascular diseases obesity metabolic syndrome and type 2 diabetes when consumed in inadequate amounts Conversely the gut microbiota plays a pivotal role in diabetes development and progression Probiotics potentially through the stimulation of short-chain fatty acid production and the induction of gut hormone secretion that influences blood glucose levels may exert beneficial effects by enhancing immune modulation increasing anti-inflammatory cytokine production reducing intestinal permeability and mitigating oxidative stress
Therefore this study aims to investigate the efficacy of fermented dietary fiber and probiotics in improving glycemic control and associated metabolic parameters in overweightobese IGR patients The ultimate goal is to establish a clinically applicable nutrition intervention strategy for glucose tolerance impaired individuals
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None