Ignite Creation Date:
2024-07-17 @ 11:38 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06499987
Status:
RECRUITING
Last Update Posted:
2024-07-15
First Post:
2024-06-26
Brief Title:
Outcome of Resection Anastomosis and Long Term Stenting With Montgomery Tube Operations in Management of Grade 3 Benign Laryngotracheal Stenosis
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Outcome of Resection Anastomosis and Long Term Stenting With Montgomery Tube Operations in Management of Grade 3 Benign Laryngotracheal Stenosis
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Laryngotracheal stenosis is a challenging problem in the field of laryngology In the majority of patients acquired stenosis of the larynx and trachea is due to accidental trauma prolonged intubations or tracheostomy Congenital stenosis caustic injury and granulomatous diseases are also etiological factors in laryngotracheal stenosis Grenier PA et al 2009
Tracheal stenosis can occur following tracheostomy or endotracheal intubation with inappropriate cuff pressure It is due to pressure necrosis at the site of the cuff Initially there is inflammation of the damaged mucosa with increased secretion and secondary infection Prolonged ischemia and secondary infection cause necrosis of the tracheal wall and exposure and sequestration of the cartilaginous rings This damage results in the formation of granulation tissue and collapse of the tracheal wall Satish Nair et al 2014
The tracheal stenosis is classified as simple which is a soft short segment web-like narrowing often limited to the mucosa only or complex stenosis which is a hard long-segment stricture with destruction of tracheal cartilages and fibrosis Post tracheostomy stenosis occurs most commonly at the stoma site or less commonly at the site where the tip of the tube has impinged on the tracheal mucosa Liu J et al 2015
The symptoms are generally insidious Most arise 1 to 6 weeks after extubation and early symptoms are often not recognized The most common symptoms include shortness of breath cough recurrent pneumonia wheezing stridor and cyanosis over time Dyspnea is often the symptom until the tracheal diameter is 50 smaller than normal When the tracheal diameter is 25 of its normal size dyspnea and stridor may occur even at rest These symptoms can be confused with other respiratory diseases Rubikas R et al 2014
Tracheal stenosis can occur following tracheostomy or endotracheal intubation with inappropriate cuff pressure It is due to pressure necrosis at the site of the cuff Initially there is inflammation of the damaged mucosa with increased secretion and secondary infection Prolonged ischemia and secondary infection cause necrosis of the tracheal wall and exposure and sequestration of the cartilaginous rings This damage results in the formation of granulation tissue and collapse of the tracheal wall Satish Nair et al 2014
The tracheal stenosis is classified as simple which is a soft short segment web-like narrowing often limited to the mucosa only or complex stenosis which is a hard long-segment stricture with destruction of tracheal cartilages and fibrosis Post tracheostomy stenosis occurs most commonly at the stoma site or less commonly at the site where the tip of the tube has impinged on the tracheal mucosa Liu J et al 2015
The symptoms are generally insidious Most arise 1 to 6 weeks after extubation and early symptoms are often not recognized The most common symptoms include shortness of breath cough recurrent pneumonia wheezing stridor and cyanosis over time Dyspnea is often the symptom until the tracheal diameter is 50 smaller than normal When the tracheal diameter is 25 of its normal size dyspnea and stridor may occur even at rest These symptoms can be confused with other respiratory diseases Rubikas R et al 2014
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None