Ignite Creation Date:
2024-05-05 @ 7:06 PM
Last Modification Date:
2024-10-26 @ 9:44 AM
Study NCT ID:
NCT00607646
Status:
COMPLETED
Last Update Posted:
2019-09-12
First Post:
2008-01-16
Brief Title:
Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus
Sponsor:
University of Maryland Baltimore
Organization:
University of Maryland Baltimore
Study Overview
Official Title:
Hypoglycemia Associated Autonomic Failure in Type 1 DM Question 3
Status:
COMPLETED
Status Verified Date:
2019-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Elevations of plasma cortisol a stress hormone during prior episodes of low blood sugar hypoglycemia appear to be responsible for the deficient responses during subsequent hypoglycemia Our specific aim is to determine if dehydroepiandrosterone DHEA a hormone with anti-corticosteroid actions can prevent hypoglycemia associated autonomic failure in type 1 diabetic volunteers
Detailed Description:
DHEA is the acronym for dehydroepiandrosterone a steroid hormone produced naturally from cholesterol in the adrenal glands of males and females It is also sold as an over-the-counter dietary supplement and seems to have anticorticosteroid effects DHEA antagonizes the effects of corticosterone on hippocampal function in rats and reduces responses to neural stress in mice In our lab we have found that administration of the DHEA to rats during antecedent hypoglycemia preserves counter-regulatory responses to subsequent hypoglycemia The purpose of this study is to determine if the same response occurs in humans
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01DK069803-03 | NIH | None | httpsreporternihgovquickSearchR01DK069803-03 |