Ignite Creation Date:
2024-07-17 @ 11:38 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06492109
Status:
RECRUITING
Last Update Posted:
2024-07-09
First Post:
2024-06-26
Brief Title:
The Peripheral Blood Multi-Omics Study on Sleep Loss
Sponsor:
First Affiliated Hospital of Zhejiang University
Organization:
First Affiliated Hospital of Zhejiang University
Study Overview
Official Title:
The Peripheral Blood Multi-Omics Study on the Association of Sleep Loss With Aging and Alzheimers Disease
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Sleep plays a role in cognitive processes such as memory processing attention processing and overall cognitive function In recent years the bidirectional relationship between sleep loss and aging as well as related neurodegenerative diseases has garnered widespread attention Sleep disorders are a typical clinical manifestation of neurodegenerative diseases such as Alzheimers disease AD and Parkinsons disease and are closely related to the progression of these diseases However current research has yet to fully elucidate the physiological responses to sleep loss across different ages and cognitive levels as well as the association and molecular basis between sleep loss aging and neurodegenerative diseases This study aims to comprehensively characterize the transcriptional and metabolic changes in peripheral blood under sleep loss in populations of different ages and cognitive levels using multi-omics approaches and to preliminarily explore the role of sleep deprivation in aging and AD
Detailed Description:
Participants meeting inclusion and exclusion criteria will include healthy subjects MCI patients and AD patients General information such as age gender education level medical history family history medication history and surgical history will be collected Cognitive assessments and sleep condition screenings will be conducted with blood samples collected before and after sleep deprivation and anxiety and depression scales administered Blood samples will be processed using standardized methods for multi-omics analysis Joint analyses with cognitive levels and sleep conditions will be performed to identify molecular biomarkers associated with age cognitive levels and key biological processes related to sleep deprivation revealing its association with aging and AD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None