Ignite Creation Date:
2024-07-17 @ 11:37 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06488768
Status:
RECRUITING
Last Update Posted:
2024-07-05
First Post:
2024-06-17
Brief Title:
Duration of Peripheral Nerve Blocks in Opioid Tolerant Individuals - A Volunteer Blinded Matched Case-control Study
Sponsor:
Charlotte Runge
Organization:
Regionshospitalet Silkeborg
Study Overview
Official Title:
Duration of Peripheral Nerve Blocks in Opioid Tolerant Individuals - A Volunteer Blinded Matched Case-control Study
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
OPITOBLOK
Brief Summary:
Do peripheral nerve blocks work shorter if you are on opioids
Background
Peripheral nerve blocks effectively alleviate postoperative pain Animal studies and human research indicate that opioid tolerance results in reduced effectiveness of local analgesics This applies to both central nerve blockade and infiltration anaesthesia The impact on peripheral nerve block in humans has not been evaluated The aim of the study is to assess the onset time and duration of a radial nerve block in opioid tolerant individuals compared to opioid naive individuals We hypothesise that peripheral nerve blocks cause shorter sensory and motor block in opioid-tolerant compared to opioid-naive counterparts
Methods
Twenty opioid-tolerant individuals will be matched by sex and age with opioid-naïve counterparts Participants will undergo an ultrasound-guided radial nerve block The onset time and duration of motor and sensory blockade will be tested and measured The primary outcome is difference in duration of sensory nerve blockade between the two groups The secondary outcomes include the onset time of sensory blockade onset time of motor blockade and difference in duration of motor nerve blockade
Perspectives
The data from this study will provide evidence for the duration of peripheral nerve block in opioid tolerant individuals and support if a specific postoperative protocol for opioid tolerant individuals is needed or it should be of special attention
Background
Peripheral nerve blocks effectively alleviate postoperative pain Animal studies and human research indicate that opioid tolerance results in reduced effectiveness of local analgesics This applies to both central nerve blockade and infiltration anaesthesia The impact on peripheral nerve block in humans has not been evaluated The aim of the study is to assess the onset time and duration of a radial nerve block in opioid tolerant individuals compared to opioid naive individuals We hypothesise that peripheral nerve blocks cause shorter sensory and motor block in opioid-tolerant compared to opioid-naive counterparts
Methods
Twenty opioid-tolerant individuals will be matched by sex and age with opioid-naïve counterparts Participants will undergo an ultrasound-guided radial nerve block The onset time and duration of motor and sensory blockade will be tested and measured The primary outcome is difference in duration of sensory nerve blockade between the two groups The secondary outcomes include the onset time of sensory blockade onset time of motor blockade and difference in duration of motor nerve blockade
Perspectives
The data from this study will provide evidence for the duration of peripheral nerve block in opioid tolerant individuals and support if a specific postoperative protocol for opioid tolerant individuals is needed or it should be of special attention
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None