Ignite Creation Date:
2024-07-17 @ 11:37 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06501287
Status:
RECRUITING
Last Update Posted:
2024-07-15
First Post:
2024-05-20
Brief Title:
Postprandial Triglyceride Impact on Coronary Atherosclerosis in Non-Diabetic Patient in Sohag University Hospital
Sponsor:
Fatma Madhy Eissa
Organization:
Sohag University
Study Overview
Official Title:
Postprandial Triglyceride Impact on Coronary Atherosclerosis in Non-Diabetic Patient in Sohag University Hospital NCT ID Not Yet Assigned
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
INTRODUCTION Cardiovascular diseases including coronary artery disease CAD are the leading cause of mortality worldwide Despite remarkable advancements in diagnostic and therapeutic approaches CAD continues to pose formidable challenges Atherosclerosis characterized by the deposition of lipids inflammatory cells and fibrous tissue within the arterial walls is the fundamental pathology underpinning CAD Atherosclerosis development and progression are closely intertwined with lipid metabolism particularly elevated levels of low-density lipoprotein cholesterol LDL-C and reduced levels of high-density lipoprotein cholesterol HDL-C 1 However emerging evidence suggests that postprandial triglyceride levels the transient increase in triglycerides following a meal may play a pivotal role in atherosclerotic processes 2 Postprandial hypertriglyceridemia has been linked to various cardiovascular risk factors including inflammation endothelial dysfunction oxidative stress and altered hemostasis 3 cardiovascular disease CVD causes death for 4 million subjects in Europe every year It causes death for women 22 million 55 than men 18 million 45 and cardiovascular CV deaths under 65 years more prevalent in men 490 000 versus 193 000 4 Endothelial dysfunction was the main cause of vascular atherosclerosis The damage of Endothelium cause lipids and macrophages accumulation mostly lowdensity lipoprotein in vessel injury site 5 Lipids considered the major cause of atherosclerosis 6 The increase of blood cholesterol especially LDL considered the main cause of the disease High levels of triglycerides could be independent risk factor for coronary artery disease CAD particularly in women Although it was suggested that high level of density lipoproteins HDLs can prohibit these risk factors Extensive examinations showed that lipid decrease the prevention of CAD in primary and secondary cases 7 The level 90 of total glyceride andor LDL and level 10 of HDL confirm dyslipidemia 8
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None