Ignite Creation Date:
2024-07-17 @ 11:35 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06497673
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-07-12
First Post:
2024-07-04
Brief Title:
Sanger Human Cell Atlasing Project
Sponsor:
The Wellcome Sanger Institute
Organization:
The Wellcome Sanger Institute
Study Overview
Official Title:
Sanger Human Cell Atlasing Project Defining Human Cells in Terms of Gene Expression Physiological StatesDevelopmental Trajectories and Location
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HCA
Brief Summary:
Cell Atlasing refers to a novel strategy to characterise cells in tissues at the molecular level in a quantitative manner The international Human Cell Atlas consortium brings together a community of biologists clinicians technologists physicists computational scientists software engineers and mathematicians to capitalise on drawing together leaders with various biological technical and computational expertise The project is based on the aim to define all human cell types in terms of their distinctive patterns of gene expression physiological states developmental trajectories and location This will pave the way to create a reference map of all human cells as a basis for understanding human health and diagnosing monitoring and treating disease
Detailed Description:
Previous methods for quantifying molecular states of cells included microarray and standard RNA-seq analysis on a tissue section RNA-seq is a technique to look at the activity of all the genes in a cell These methods estimate the activity of any given gene by averaging the signal from millions of cells Given the heterogeneity of cell populations iehow uniform they are measurement of the mean values of signals overlooks the internal interactions and differences within a cell population that may be crucial for maintaining normal tissue function and facilitating disease progression
The Sanger Human Cell Atlasing project will adopt various genomic approaches that will provide genome-wide information in a single experiment This project aims to scale up the single cell genomics and high-throughput highly multiplex spatial gene expression profiling approaches Coupled with powerful computational methods this strategy will produce a comprehensive and systematic reference map of human cells providing a fundamental blueprint of cell states for both basic biological research and clinical practice
The Sanger Human Cell Atlasing project will adopt various genomic approaches that will provide genome-wide information in a single experiment This project aims to scale up the single cell genomics and high-throughput highly multiplex spatial gene expression profiling approaches Coupled with powerful computational methods this strategy will produce a comprehensive and systematic reference map of human cells providing a fundamental blueprint of cell states for both basic biological research and clinical practice
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None