Ignite Creation Date:
2024-07-17 @ 11:34 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06464965
Status:
RECRUITING
Last Update Posted:
2024-06-18
First Post:
2024-06-13
Brief Title:
Clinical Study of Cord Blood-Derived CAR-NK Cells in Gastric Cancer and Pancreatic Cancer
Sponsor:
Zhejiang Provincial Peoples Hospital
Organization:
Zhejiang Provincial Peoples Hospital
Study Overview
Official Title:
A Phase I Clinical Study of Cord Blood-Derived CAR-NK Cells Targeting Claudin182 in the Treatment of Advanced Gastric Cancer and Advanced Pancreatic Cancer
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Main Objective To study the maximum tolerated dose MTD and dose-dependent toxicity DLT of cord blood-derived CAR-NK cells CB CAR-NK182 targeting Claudin182 in patients with advanced gastric cancer and advanced pancreatic cancer
Secondary Objective To evaluate the efficacy of CB CAR-NK182 in patients with advanced gastric cancer and advanced pancreatic cancer overall objective tumor response rate ORR disease control rate DCR progression-free survival PFS overall survival OS duration of response DOR etc
To evaluate the CAR-NK amplification and persistence of CB CAR-NK182 in the blood of patients with advanced gastric cancer and advanced pancreatic cancer
Secondary Objective To evaluate the efficacy of CB CAR-NK182 in patients with advanced gastric cancer and advanced pancreatic cancer overall objective tumor response rate ORR disease control rate DCR progression-free survival PFS overall survival OS duration of response DOR etc
To evaluate the CAR-NK amplification and persistence of CB CAR-NK182 in the blood of patients with advanced gastric cancer and advanced pancreatic cancer
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None