Ignite Creation Date:
2024-07-17 @ 11:33 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06478784
Status:
RECRUITING
Last Update Posted:
2024-06-27
First Post:
2024-05-01
Brief Title:
Effects of Resistance Training in Multiple Sclerosis a Randomized Trial
Sponsor:
Hospital Clínico Universitario de Valladolid
Organization:
Hospital Clínico Universitario de Valladolid
Study Overview
Official Title:
Effects of Resistance Training in Multiple Sclerosis a Randomized Trial ACTIVE Physical Activity and Its Impact on Patients With Multiple Sclerosis
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ACTIVE
Brief Summary:
This is a longitudinal study to examine the effects of a short-term training program on neurofilamet and GFAP plasma levels Participants will be divided in two groups control group moderate aerobic training and active group resistance training The change in biomarkers will be analyzed pre and post intervention in both groups Differences between groups will be also evaluated by investigators
Detailed Description:
Multiple sclerosis is a dysimmune and neurodegenerative disease of the central nervous system Despite highly effective drug multiple sclerosis represents the main cause of non-traumatic disability in young people Interventions based on physical exercise have a positive impact on the course of the disease although the pathophysiological mechanisms responsible for this benefit remain unknown This project aims to investigate the impact of physical exercise on neuronal destruction in patients with multiple sclerosis
To do this the investigators will study the evolution of the concentrations of two markers of neuronal injury acidic gliofibrillary protein GFAP and light chain neurofilaments Nfl in two groups of patients a control group and a second group subjected to a supervised resistance physical exercise program performed during 10 weeks Marker values will be compared before and after the intervention and between groups The results will allow the investigators to delve into the pathophysiology of multiple sclerosis and the mechanism through which physical exercise impacts on the disease In addition the investigators will generate knowledge that will allow us to reinforce the idea of integrating physical exercise as part of the treatment in multiple sclerosis
Project within the framework of the GRSGerencia Regional de Salud Castilla y Léon 2810A12023
To do this the investigators will study the evolution of the concentrations of two markers of neuronal injury acidic gliofibrillary protein GFAP and light chain neurofilaments Nfl in two groups of patients a control group and a second group subjected to a supervised resistance physical exercise program performed during 10 weeks Marker values will be compared before and after the intervention and between groups The results will allow the investigators to delve into the pathophysiology of multiple sclerosis and the mechanism through which physical exercise impacts on the disease In addition the investigators will generate knowledge that will allow us to reinforce the idea of integrating physical exercise as part of the treatment in multiple sclerosis
Project within the framework of the GRSGerencia Regional de Salud Castilla y Léon 2810A12023
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None