Ignite Creation Date:
2024-07-17 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06498102
Status:
COMPLETED
Last Update Posted:
2024-07-12
First Post:
2024-06-21
Brief Title:
Time-restricted Feeding Improves Basal Fat Oxidation and Body Composition But Not Fat Oxidation During Exercise
Sponsor:
Hacettepe University
Organization:
Hacettepe University
Study Overview
Official Title:
Six Weeks of Time-restricted Feeding Improves Basal Fat Oxidation and Body Composition But Not Fat Oxidation During Exercise in Young Males A Randomized Controlled Trial
Status:
COMPLETED
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Time-restricted feeding is one of the IF models with significant advantages beyond other IF models such as simplicity and flexibility where individuals limit their eating window to specific hours of the day with a fasting period of at least 12 hours Ample evidence in humans suggests that prolonged daily cycles of feeding and fasting when aligned with the circadian rhythm as in the TRF regimen can alleviate metabolic diseases Furthermore research supports a range of health benefits associated with TRF programs in diverse populations including improvements in body composition and insulin sensitivity appetite regulation and achieving a more balanced hunger sensation Moreover adopting a 6-hour eating window followed by an 18-hour fasting period can elicit a metabolic shift from relying on glucose to utilizing ketones for energy which is associated with extended lifespan and a reduced risk of various diseases including type 2 diabetes and obesity This study aimed to determine the effect of a 6-week TRF on resting and exercise substrate oxidation and changes in blood markers linked to cardiometabolic health
Detailed Description:
The aim of this study was to determine the effects of a 6-week TRF program on resting and exercise substrate oxidation and examine changes in body composition and blood markers linked to cardiometabolic health in recreationally active young males It was hypothesized that compared to controls TRF would improve body composition blood markers associated with cardiometabolic health and increase substrate oxidation during rest and exercise
Experimental approach to the problem
Participants reported to the laboratory on 4 separate occasions Initially a familiarization session for VO2max testing was conducted on a cycle ergometer In the second visit participants repeated VO2max test to determine their cardiorespiratory fitness and this test created the intensity for the submaximal exercise test A minimum of 48 hours after the VO2max test and an overnight fast body composition resting metabolic rate RMR and substrate oxidation during submaximal exercise were assessed All measurements were performed between 0800 am and 1200 noon in order to eliminate the effect of circadian rhythm Subsequently participants were randomly assigned to either TRF or control group The TRF group received comprehensive nutrition education from a dietitian and was directed to adhere to the 168 program for 6 weeks limiting their eating window to 8 hours daily while the control group was asked to maintain their eating habits To assess participant quality of life the 12-item Short Form Health Survey SF-12 developed by Ware et al was administered before and after the 6-week intervention period 38 All participants were asked to maintain their daily physical activity levels throughout the study A 7-day food diary was completed by all participants at study initiation and during the third and sixth week After completing the six-week program all participants underwent post-tests identical to the pre-tests Venous blood samples were collected from all participants following an overnight fast at baseline and after 6 weeks
Experimental approach to the problem
Participants reported to the laboratory on 4 separate occasions Initially a familiarization session for VO2max testing was conducted on a cycle ergometer In the second visit participants repeated VO2max test to determine their cardiorespiratory fitness and this test created the intensity for the submaximal exercise test A minimum of 48 hours after the VO2max test and an overnight fast body composition resting metabolic rate RMR and substrate oxidation during submaximal exercise were assessed All measurements were performed between 0800 am and 1200 noon in order to eliminate the effect of circadian rhythm Subsequently participants were randomly assigned to either TRF or control group The TRF group received comprehensive nutrition education from a dietitian and was directed to adhere to the 168 program for 6 weeks limiting their eating window to 8 hours daily while the control group was asked to maintain their eating habits To assess participant quality of life the 12-item Short Form Health Survey SF-12 developed by Ware et al was administered before and after the 6-week intervention period 38 All participants were asked to maintain their daily physical activity levels throughout the study A 7-day food diary was completed by all participants at study initiation and during the third and sixth week After completing the six-week program all participants underwent post-tests identical to the pre-tests Venous blood samples were collected from all participants following an overnight fast at baseline and after 6 weeks
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None