Ignite Creation Date:
2024-07-17 @ 11:29 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06462599
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-17
First Post:
2024-06-12
Brief Title:
Osteopontin Gene Polymorphism in Stroke Patients in Egypt
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Association of Osteopontin Gene Polymorphisms With Susceptibility and Prognosis of Ischemic Stroke in Egyptian Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to investigate the correlation of serum osteopontin level as a predictior and a prognostic factor in upper egyptian patients and correlation between Osteopontin Gene Polymorphisms and serum level of osteopontin in ischaemic stroke patients
Detailed Description:
The Global Burden of Disease estimated that one person in four aged 25 years will have a stroke in the rest of herhis life Among them ischemic stroke IS represents 80
Stroke is accompanied by a neuroinflammatory response involving immune system These long-term processes following IS are still far from being understood So despite the significant improvement in the diagnosis and treatment of IS the disability and mortality rate of IS are still rising An assessment of the prognostic risk of IS should be carried out as early as possible and corresponding interventions should be adopted clinically in order to have a significant impact on the prognosis of patients with IS
Predicting the outcome in individual patients solely based on clinical and radiological parameters is challenging for clinicians Measuring blood biomarkers associated with inflammation endothelial function matrix remodeling and immune functions may improve prediction performance
Osteopontin OPN is a matricellular protein participating in many physiological and pathologic processes including wound healing bone turnover tumor genesis inflammation and immune responses It is well accepted that OPN is an important mediator in stroke pathophysiology OPN expression is upregulated in microglia surrounding the infarcted area and in microglia and infiltrating macrophages in the infarct area OPN and microglia seems to exhibit an intimate relationship in stroke with rather beneficial functions for the clinical outcome However the role of OPN in stroke-related diseases as atherosclerosis and diabetes should be further disentangled as in this early phase of disease OPN may ultimately culminate in cerebrovascular dysfunction OPN may exert opposing effects and should be therefore addressed differently
Stroke is accompanied by a neuroinflammatory response involving immune system These long-term processes following IS are still far from being understood So despite the significant improvement in the diagnosis and treatment of IS the disability and mortality rate of IS are still rising An assessment of the prognostic risk of IS should be carried out as early as possible and corresponding interventions should be adopted clinically in order to have a significant impact on the prognosis of patients with IS
Predicting the outcome in individual patients solely based on clinical and radiological parameters is challenging for clinicians Measuring blood biomarkers associated with inflammation endothelial function matrix remodeling and immune functions may improve prediction performance
Osteopontin OPN is a matricellular protein participating in many physiological and pathologic processes including wound healing bone turnover tumor genesis inflammation and immune responses It is well accepted that OPN is an important mediator in stroke pathophysiology OPN expression is upregulated in microglia surrounding the infarcted area and in microglia and infiltrating macrophages in the infarct area OPN and microglia seems to exhibit an intimate relationship in stroke with rather beneficial functions for the clinical outcome However the role of OPN in stroke-related diseases as atherosclerosis and diabetes should be further disentangled as in this early phase of disease OPN may ultimately culminate in cerebrovascular dysfunction OPN may exert opposing effects and should be therefore addressed differently
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None