Ignite Creation Date:
2024-07-17 @ 11:29 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06463808
Status:
RECRUITING
Last Update Posted:
2024-06-18
First Post:
2023-12-13
Brief Title:
Effect of Recombinant Human Brain Natriuretic Peptide on Ventricular Remodeling and Cardiac Function in Patients With Acute Anterior Myocardial Infraction Undergoing Percutaneous Coronary Intervention
Sponsor:
The First Affiliated Hospital with Nanjing Medical University
Organization:
The First Affiliated Hospital with Nanjing Medical University
Study Overview
Official Title:
Effect of Recombinant Human Brain Natriuretic Peptide on Ventricular Remodeling and Cardiac Function in Patients With Acute Anterior Myocardial Infraction Undergoing Percutaneous Coronary Intervention
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is designed to evaluate the efficacy and safety of Recombinant Human Brain Natriuretic Peptide rhBNP in improving ventricular remodeling and cardiac function after acute anterior myocardial infarction undergoing percutaneous coronary intervention 100 patients with acute anterior myocardial infarction after primary Percutaneous Coronary Intervention pPCI are randomly assigned 11 to rhBNP groupn50 and control groupn50 with follow-up of 24 weeks Both groups are treated with standard therapy of AAMI with the rhBNP group intravenous dripping rhBNP after pPCI for 3 days and the control group treated with placebo at the same time The primary endpoint is the change in N terminal pro-B-type natriuretic peptideNT-proBNP and cardiac troponin TcTnT levelThe secondary endpoint is the change in 24-week echocardiographic including left ventricle ejection fraction LVEF left ventricular end-diastolic volume index LVEDVI and left ventricular end-systolic volume index LVESVI arrhythmia and cardiovascular events death cardiac arrest or cardiopulmonary resuscitation hospitalization due to heart failure or angina pectoris
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None