Ignite Creation Date:
2024-07-17 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06464380
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-25
First Post:
2024-06-13
Brief Title:
Anti-cancer Potentiality of Saffron Against Hepatocellular Carcinoma
Sponsor:
Ain Shams University
Organization:
Ain Shams University
Study Overview
Official Title:
Anti Cancer Potential of Saffron in Hepatocellular Carcinoma
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Saffron has recently gained considerable interest for its capacity to interfere with cancer at initiation and promotion stages as well as for cancer treatment Although saffron and its constituents have been shown to have antitumorigenic and proapoptotic activities in different cancer cell lines
The aim of the current investigation is to identify the anti-cancer potentiality of saffron on hepatocellular carcinoma patients
The aim of the current investigation is to identify the anti-cancer potentiality of saffron on hepatocellular carcinoma patients
Detailed Description:
Hepatocellular carcinoma HCC is the fifth most common cancer and the third leading cause of cancer mortality in the world Chronic infection with hepatitis B and C is the major risk factors for HCC worldwide Other factors that contribute to the formation of HCC include exposure to environmental carcinogens iron overload fatty liver disease and alcohol abuse
there has been a sustained rise in its incidence in both developing and developed countries Despite the growing therapeutic options for patients with cancer their efficacy is time-limited and non-curative Hence to overcome these drawbacks an incessant screening for superior and safer drugs has been ongoing for numerous decades resulting in the detection of anti-cancer properties of several phytochemicals Chemoprevention using readily available natural substances from vegetables fruits herbs and spices is one of the significantly important approaches for cancer prevention in the present era Among the spices saffron has generated interest because pharmacological experiments have established numerous beneficial properties including radical scavenging anti-mutagenic and immuno-modulating effects
Saffron is a naturally derived plant product from the dried stigma of the Crocus sativus flower family Iridaceae that may have biologically useful properties In fact saffron extract and its biologically active compounds including crocin crocetin carotene and safranal have been shown both in vitro and in vivo to possess antioxidant anticancer anti-inflammatory and memory-improving properties Saffron is also used in folk medicine as an antispasmodic antidepressant and aphrodisiac Furthermore it is one of the most commonly used species around the world for flavouring and colouring foods
Saffron has recently gained considerable interest for its capacity to interfere with cancer at initiation and promotion stages as well as for cancer treatment Although saffron and its constituents have been shown to have antitumorigenic and proapoptotic activities in different cancer cell lines
there has been a sustained rise in its incidence in both developing and developed countries Despite the growing therapeutic options for patients with cancer their efficacy is time-limited and non-curative Hence to overcome these drawbacks an incessant screening for superior and safer drugs has been ongoing for numerous decades resulting in the detection of anti-cancer properties of several phytochemicals Chemoprevention using readily available natural substances from vegetables fruits herbs and spices is one of the significantly important approaches for cancer prevention in the present era Among the spices saffron has generated interest because pharmacological experiments have established numerous beneficial properties including radical scavenging anti-mutagenic and immuno-modulating effects
Saffron is a naturally derived plant product from the dried stigma of the Crocus sativus flower family Iridaceae that may have biologically useful properties In fact saffron extract and its biologically active compounds including crocin crocetin carotene and safranal have been shown both in vitro and in vivo to possess antioxidant anticancer anti-inflammatory and memory-improving properties Saffron is also used in folk medicine as an antispasmodic antidepressant and aphrodisiac Furthermore it is one of the most commonly used species around the world for flavouring and colouring foods
Saffron has recently gained considerable interest for its capacity to interfere with cancer at initiation and promotion stages as well as for cancer treatment Although saffron and its constituents have been shown to have antitumorigenic and proapoptotic activities in different cancer cell lines
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None