Ignite Creation Date:
2024-07-17 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06471244
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-24
First Post:
2024-05-20
Brief Title:
Development of Electroencephalography EEG and Magnetoencephalography MEG Source Reconstruction With Fast Multipole Method
Sponsor:
Worcester Polytechnic Institute
Organization:
Worcester Polytechnic Institute
Study Overview
Official Title:
Development of Electroencephalography EEG and Magnetoencephalography MEG Source Reconstruction With Fast Multipole Method
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this clinical trial is to learn if an advanced 256 dry electrode EEG cap augmented with MEG readings and coupled with a new high-resolution fast brain modeling software gives a better EEG and MEG source localization in real time The main questions it aims to answer are
Does the testbed better localize brain sources for finger movement
Does the testbed better localize brain sources for median nerve stimulation
Does the testbed better localize brain sources for speech processing
Researchers will compare the predicted cortical locations with MEG data and known anatomical locations of the neuronal generators
Participants will
Undergo Magnetic Resonance Imaging MRI scans for brain and head model creation
Undergo three different EEG tests
Undergo three different MEG tests
Does the testbed better localize brain sources for finger movement
Does the testbed better localize brain sources for median nerve stimulation
Does the testbed better localize brain sources for speech processing
Researchers will compare the predicted cortical locations with MEG data and known anatomical locations of the neuronal generators
Participants will
Undergo Magnetic Resonance Imaging MRI scans for brain and head model creation
Undergo three different EEG tests
Undergo three different MEG tests
Detailed Description:
Magnetic Resonance Imaging MRI headneck scans of 30 healthy subjects using the 7 Tesla Siemens Scanner will be performed at the Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany with 0507 mm isotropic resolution for both T1 and T2 imaging sequences Construction of computational head models from the MRI data using FreeSurfer and Charm segmentation software packages will be performed at Worcester Polytechnic Institute
On-skin voltage recordings will be done with 256 dry electrodes Our EEG protocols will collect 240 trials per subject 3 runs of 80 trials each German volunteers will be tapping with their right hand index finger The corresponding neuronal generators are located in the M1INDEXFINGERS1INDEXFINGER areas primary motorsomatosensory cortex at different latencies
On-skin voltage recordings will be done with 256 dry electrodes Our EEG protocols will collect 240 trials per subject 3 runs of 80 trials each Electrical stimuli over the median nerve at the right wrist will be delivered using brief transcutaneous pulses every 15 seconds The task is to respond to each stimulus by pushing a button with the left-hand index finger This generates EEG evoked responses in the S1HAND area primary somatosensory cortex contralateral to the nerve stimuli and the M1HAND area primary motor cortex at different latencies The P20N20 response peaking at about 20 ms is targeted since at this latency its neuronal generators are well-known to be located in the posterior wall of the central sulcus in the Brodmann area 3b
On-skin voltage recordings will be done with 256 dry electrodes Our EEG protocols will collect 240 trials per subject 3 runs of 80 trials each German sentences will be played to the volunteers and the volunteers have to fulfill a semantic task This generates EEG evoked responses in the known areas of the Primary Auditory Cortex PAC
On-skin voltage recordings will be done with 256 dry electrodes Our MEG protocols will collect 240 trials per subject 3 runs of 80 trials each German volunteers will be tapping with their right hand index finger The corresponding neuronal generators are located in the M1INDEXFINGERS1INDEXFINGER areas primary motorsomatosensory cortex at different latencies
On-skin voltage recordings will be done with 256 dry electrodes Our MEG protocols will collect 240 trials per subject 3 runs of 80 trials each Electrical stimuli over the median nerve at the right wrist will be delivered using brief transcutaneous pulses every 15 seconds The task is to respond to each stimulus by pushing a button with the left-hand index finger This generates MEG evoked responses in the S1HAND area primary somatosensory cortex contralateral to the nerve stimuli and the M1HAND area primary motor cortex at different latencies The P20N20 response peaking at about 20 ms is targeted since at this latency its neuronal generators are well-known to be located in the posterior wall of the central sulcus in the Brodmann area 3b
On-skin voltage recordings will be done with 256 dry electrodes Our MEG protocols will collect 240 trials per subject 3 runs of 80 trials each German sentences will be played to the volunteers and the volunteers have to fulfill a semantic task This generates EEG evoked responses in the known areas of the Primary Auditory Cortex PAC
The main questions it aims to answer are
Does the proposed high-resolution testbed better localize brain sources for finger movement
Does the proposed high-resolution testbed better localize brain sources for median nerve stimulation
Does the proposed high-resolution testbed better localize brain sources for speech processing
On-skin voltage recordings will be done with 256 dry electrodes Our EEG protocols will collect 240 trials per subject 3 runs of 80 trials each German volunteers will be tapping with their right hand index finger The corresponding neuronal generators are located in the M1INDEXFINGERS1INDEXFINGER areas primary motorsomatosensory cortex at different latencies
On-skin voltage recordings will be done with 256 dry electrodes Our EEG protocols will collect 240 trials per subject 3 runs of 80 trials each Electrical stimuli over the median nerve at the right wrist will be delivered using brief transcutaneous pulses every 15 seconds The task is to respond to each stimulus by pushing a button with the left-hand index finger This generates EEG evoked responses in the S1HAND area primary somatosensory cortex contralateral to the nerve stimuli and the M1HAND area primary motor cortex at different latencies The P20N20 response peaking at about 20 ms is targeted since at this latency its neuronal generators are well-known to be located in the posterior wall of the central sulcus in the Brodmann area 3b
On-skin voltage recordings will be done with 256 dry electrodes Our EEG protocols will collect 240 trials per subject 3 runs of 80 trials each German sentences will be played to the volunteers and the volunteers have to fulfill a semantic task This generates EEG evoked responses in the known areas of the Primary Auditory Cortex PAC
On-skin voltage recordings will be done with 256 dry electrodes Our MEG protocols will collect 240 trials per subject 3 runs of 80 trials each German volunteers will be tapping with their right hand index finger The corresponding neuronal generators are located in the M1INDEXFINGERS1INDEXFINGER areas primary motorsomatosensory cortex at different latencies
On-skin voltage recordings will be done with 256 dry electrodes Our MEG protocols will collect 240 trials per subject 3 runs of 80 trials each Electrical stimuli over the median nerve at the right wrist will be delivered using brief transcutaneous pulses every 15 seconds The task is to respond to each stimulus by pushing a button with the left-hand index finger This generates MEG evoked responses in the S1HAND area primary somatosensory cortex contralateral to the nerve stimuli and the M1HAND area primary motor cortex at different latencies The P20N20 response peaking at about 20 ms is targeted since at this latency its neuronal generators are well-known to be located in the posterior wall of the central sulcus in the Brodmann area 3b
On-skin voltage recordings will be done with 256 dry electrodes Our MEG protocols will collect 240 trials per subject 3 runs of 80 trials each German sentences will be played to the volunteers and the volunteers have to fulfill a semantic task This generates EEG evoked responses in the known areas of the Primary Auditory Cortex PAC
The main questions it aims to answer are
Does the proposed high-resolution testbed better localize brain sources for finger movement
Does the proposed high-resolution testbed better localize brain sources for median nerve stimulation
Does the proposed high-resolution testbed better localize brain sources for speech processing
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None