Ignite Creation Date:
2024-07-17 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06473714
Status:
RECRUITING
Last Update Posted:
2024-06-26
First Post:
2024-06-19
Brief Title:
Effects of Transcranial Direct Current Stimulation tDCS on Inhibition and Brain Function in Primary Progressive Aphasia
Sponsor:
Centre Hospitalier Universitaire de Nice
Organization:
Centre Hospitalier Universitaire de Nice
Study Overview
Official Title:
Effects of Transcranial Direct Current Stimulation tDCS on Inhibition and Brain Function in Primary Progressive Aphasia
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Stim-APHA
Brief Summary:
Primary progressive aphasia PPA is a focal dementia characterized by primary impairment of language abilities and functional disturbances associated with language
Although PPA is a progressive disorder new techniques are being proposed to try to activate parts of the brain previously thought to be potentially inactive due to the possibility of neuroplasticity This concept refers to our brains modularity and learning potential Transcranial direct current stimulation is a powerful neuromodulatory technique in which a small current is applied to the participants scalp through the targeted positioning of an anode and a cathode The positive or anodal stimulation of tDCS is supposed to increase neuronal activity under the electrode while cathodal stimulation is supposed to do the opposite
This project will provide new insights into the nature of the neural activity underlying executive functions in people with primary progressive aphasia compared to those without The investigators expect to find reduced amplitude of electrophysiological responses and lower accuracy in people with primary progressive aphasia compared with healthy controls Given the results of previous studies showing the efficacy of tDCS protocols in the treatment of aphasia the investigators might expect them to improve executive functions If so the investigators expect significantly greater electrophysiological responses after stimulation sessions compared with sham conditions This project is of great clinical relevance This research will improve current therapeutic protocols used in the treatment of PPA by providing critical findings on whether and how the use of tDCS improves executive functions Crucially the research will advance knowledge of executive function decline as a sensitive marker of PPA informing us about the possibility of early detection of this disorder At the same time the investigators will analyze the possibility of controlling symptomatological evolution via the analysis of acoustic and vocal markers This will enable us to observe the evolution of sensory markers such as acoustic markers according to symptomatological evolution This will enable us to check whether acoustic markers correlate with the patients level of symptomatological impairment andor pathological physiological data
Although PPA is a progressive disorder new techniques are being proposed to try to activate parts of the brain previously thought to be potentially inactive due to the possibility of neuroplasticity This concept refers to our brains modularity and learning potential Transcranial direct current stimulation is a powerful neuromodulatory technique in which a small current is applied to the participants scalp through the targeted positioning of an anode and a cathode The positive or anodal stimulation of tDCS is supposed to increase neuronal activity under the electrode while cathodal stimulation is supposed to do the opposite
This project will provide new insights into the nature of the neural activity underlying executive functions in people with primary progressive aphasia compared to those without The investigators expect to find reduced amplitude of electrophysiological responses and lower accuracy in people with primary progressive aphasia compared with healthy controls Given the results of previous studies showing the efficacy of tDCS protocols in the treatment of aphasia the investigators might expect them to improve executive functions If so the investigators expect significantly greater electrophysiological responses after stimulation sessions compared with sham conditions This project is of great clinical relevance This research will improve current therapeutic protocols used in the treatment of PPA by providing critical findings on whether and how the use of tDCS improves executive functions Crucially the research will advance knowledge of executive function decline as a sensitive marker of PPA informing us about the possibility of early detection of this disorder At the same time the investigators will analyze the possibility of controlling symptomatological evolution via the analysis of acoustic and vocal markers This will enable us to observe the evolution of sensory markers such as acoustic markers according to symptomatological evolution This will enable us to check whether acoustic markers correlate with the patients level of symptomatological impairment andor pathological physiological data
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None