Ignite Creation Date:
2024-07-17 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06498336
Status:
RECRUITING
Last Update Posted:
2024-07-12
First Post:
2024-06-27
Brief Title:
miRNA in Septic Acute Kidney Injury
Sponsor:
University Hospital Ostrava
Organization:
University Hospital Ostrava
Study Overview
Official Title:
Specific miRNA Associated With Endothelial Dysfunction and Mitochondrial Damage in Patients With Septic Acute Kidney Injury
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Acute kidney injury is a common and serious complication of sepsis and septic shock which may be associated with a worse outcome of the patients condition The exact pathophysiological mechanism of septic acute kidney injury remains a challenge One of the possible causes appears to be endothelial dysfunction and mitochondrial damage of renal tubular cells The aim of this study is to identify specific microRNAs associated with these pathophysiological events in sepsis and septic acute kidney injury And to establish a new potential diagnostic or therapeutic target for the prevention or treatment of septic acute kidney injury
Detailed Description:
Sepsis is generally characterized as a life-threatening organ dysfunction and dysregulating host reaction to the infection eg bacterial viral mycotic 1 Typical pathophysiological processes of sepsis include systemic inflammation immune suppression activation of the clotting cascade and increase of endothelial vascular permeability with subsequent leak of fluids into the interstitial space One of the most important organ damage due to ongoing sepsis is acute kidney injury AKI which is also a predictor of mortality in critically ill patients The exact pathophysiology of septic AKI remains a challenging and poorly understood mechanism A decrease of oxygen delivery to the tissues during the septic shock and usually high oxygen consumption of renal tubular cells make them prone to ischemia injury with consequences in tubular cell death Among potential immune inflammatory response biomarkers in sepsis and septic shock might be promising pentraxin 3 PTX3 which plays an important role in endothelial dysfunction with several pathogenic pathways activation Recently has been shown the positive effect of PTX3 on the inhibition of reactive oxygen species mitochondrial injury and apoptosis pathway in AKI 34 Another promising urinary or serum biomarker of AKI seems to be uromodulin which is dynamically regulated in response to sepsis Serum uromodulin concentrations decrease during septic human AKI development and are associated with increased renal and systemic oxidative damage 567 MicroRNAs are small non-coding RNAs that have been reported to be useful biomarkers for AKI development or potential target for AKI treatment Determination of serum PTX3 and uromodulin concomitantly with specific circulating miRNAs associated with PTX3 and uromodulin-specific signaling pathways in critically ill septic patients could bring new insights to septic AKI pathophysiology and contribute to future development of new preventive or therapeutic options in septic patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| RVO-FNOs2024 | OTHER_GRANT | None | None |