Ignite Creation Date:
2024-07-17 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06471894
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-25
First Post:
2024-06-18
Brief Title:
Neural Circuit Mechanism of Inflammatory Bowel Disease Combined With Depression
Sponsor:
LanZhou University
Organization:
LanZhou University
Study Overview
Official Title:
Study on the Neural Circuit Mechanism of Regulating GABA by Gut Microbiota in Inflammatory Bowel Disease Combined With Depression
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NCMOIBDCWD
Brief Summary:
The goal of this observational study is to understand the effects of gut microbiota dysbiosis treatment in patients with inflammatory bowel disease IBD combined with depression The main question it aims to answer is
Does fecal microbiota transplantation FMT improve depression symptoms in IBD patients by altering GABA levels in the medial prefrontal cortex
Participants already undergoing fecal microbiota transplantation FMT as part of their regular medical care for IBD and comorbid depression will undergo regular assessments of GABA levels gut microbiota and depression symptoms for the duration of the study
Does fecal microbiota transplantation FMT improve depression symptoms in IBD patients by altering GABA levels in the medial prefrontal cortex
Participants already undergoing fecal microbiota transplantation FMT as part of their regular medical care for IBD and comorbid depression will undergo regular assessments of GABA levels gut microbiota and depression symptoms for the duration of the study
Detailed Description:
The high incidence of inflammatory bowel disease IBD combined with depression increases the risk of disease recurrence and treatment failure Previous research by our team has found a positive correlation between decreased levels of the inhibitory neurotransmitter γ-aminobutyric acid GABA in the medial prefrontal cortex of IBD patients and the severity of depression However the underlying pathological mechanisms remain unknown Prior studies have suggested that GABA regulates activity within neural circuits in the brain and the levels of GABA in the brain are influenced by the gut microbiota Based on this premise our study aims to treat gut microbiota dysbiosis in IBD patients with comorbid depression using fecal microbiota transplantation FMT Our team will analyze the correlation between changes in GABA levels in the medial prefrontal cortex and gut microbiota using techniques such as metagenomics metabolomics and magnetic resonance spectroscopy imaging Additionally resting-state functional magnetic resonance imaging fMRI is used to perform dynamic causal modeling of the neural circuit in the brain to elucidate the regulatory mechanism of GABA level changes on these circuits Finally the investigators will validate the research findings using a dextran sulfate sodium DSS-induced colitis mouse model to explore the neurochemical mechanisms underlying IBD comorbid with depression The results of this study will not only provide a deeper understanding of the regulatory role of changes in brain GABA levels on neural circuits but also offer a theoretical basis for the use of fecal microbiota transplantation in treating gut microbiota dysbiosis in IBD patients and prevent complications such as depression
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None