Ignite Creation Date:
2024-07-17 @ 11:16 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06501495
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-15
First Post:
2024-07-01
Brief Title:
Links Between Cognitive Deficits During Normal or Pathological Aging and Slow Waves Measured in EEG
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Slow Waves During Sleep and Wakefulness a Common Denominator for Cognitive and Attentional Disorders in Normal and Pathological Aging Exploratory Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MemoAge
Brief Summary:
With age memory processes encoding consolidation and retrieval as well as daytime vigilance are altered Sleep is also impaired in older adults notably slow waves that are known to play a key role in memory consolidation Interestingly some slow waves can also be detected in EEG recordings during wakefulness and have been related to vigilance fluctuations
The investigators believe that slow waves during both sleep and wakefulness could constitute a common biomarker of sleep disturbances and daytime vigilance problems A dysregulation of slow waves could thus explain the impact of aging on the different memory processes Since alterations in memory capacity attention and sleep quality are further exacerbated in patients with Alzheimers disease AD the investigators propose to study the links between aging normal and pathological sleep and daytime vigilance alterations and their impacts on the different key stages of memory
The investigators will examine the associations between slow waves and changes in memory and vigilance in normal and pathological aging by studying young adults seniors without cognitive disorders and patients with prodromal AD By replaying sensory cues associated with learning material during sleep the investigators will also evaluate the effectiveness of auditory stimulation during sleep to enhance memory consolidation in older adults without and without cognitive deficits
Overall this study aims to better understand the relationships between slow waves aging memory and vigilance providing insights into cognitive decline and potential interventions in aging and Alzheimers disease
The investigators believe that slow waves during both sleep and wakefulness could constitute a common biomarker of sleep disturbances and daytime vigilance problems A dysregulation of slow waves could thus explain the impact of aging on the different memory processes Since alterations in memory capacity attention and sleep quality are further exacerbated in patients with Alzheimers disease AD the investigators propose to study the links between aging normal and pathological sleep and daytime vigilance alterations and their impacts on the different key stages of memory
The investigators will examine the associations between slow waves and changes in memory and vigilance in normal and pathological aging by studying young adults seniors without cognitive disorders and patients with prodromal AD By replaying sensory cues associated with learning material during sleep the investigators will also evaluate the effectiveness of auditory stimulation during sleep to enhance memory consolidation in older adults without and without cognitive deficits
Overall this study aims to better understand the relationships between slow waves aging memory and vigilance providing insights into cognitive decline and potential interventions in aging and Alzheimers disease
Detailed Description:
Introduction Aging is accompanied by cognitive decline particularly affecting memory functions Additionally both the quantity and quality of sleep decrease with advancing age specifically altering sleep oscillations such as slow waves that are involved in the reactivation of memories and are thus central to memory consolidation
Aging is also associated with difficulties in maintaining daytime vigilance even after a period of rest impacting cognitive function including the encoding and retrieval of memories Interestingly recent studies have revealed the existence of sleep intrusions in the form of slow waves in wakefulness EEG recordings These have been associated with subjective and objective markers of fatigue predict transient lapses in attention and are particularly present after sleep deprivation the investigators believe that slow waves during both sleep and wakefulness could constitute a common biomarker of sleep disturbances and daytime vigilance problems A dysregulation of slow waves fewer during sleep more during wakefulness could thus explain the impact of aging on the three fundamental stages of the memory process encoding consolidation and retrieval Since alterations in memory capacity attention and sleep quality are further exacerbated in patients with Alzheimers disease AD the investigators propose to study the links between aging normal and pathological sleep and daytime vigilance alterations and their impacts on the different key stages of memory
Aims Our main objective is to test the associations between slow waves during sleep and wakefulness and the alterations in memory and vigilance during normal and pathological aging by studying young adults seniors without cognitive disorders and patients of the same age with prodromal AD
Additionally the investigators aim to test the efficiency of targeted memory reactivation TMR in older adults with and without cognitive deficits TMR is a technique that has been showed to boost memory consolidation in young adults and mice by replaying during sleep sensory cues that have been previously associated with the learning material
Methods Participants To do so the stydy will include three groups young adults 18-35 yo older adults without cognitive deficits 65-80 yo and older adults of the same age and with cognitive deficits patients with prodromal Alzheimers disease Prodromal stage of Alzheimers disease diagnosis will be performed by trained neurologists at the at the Memory and Alzheimers Disease Institute IM2A of the Pitié-Salpêtrière Hospital according to international diagnostic criteria as a clinical phenotype of progressive amnestic syndrome of the hippocampal type associated with biological markers of Alzheimers disease from lumbar puncture Aβ 600 pgmL and ptau 60 pgmL During their clinical follow-up at the IM2A patients diagnosed with prodromal AD will be offered the opportunity to participate in the study in agreement with their attending physician Healthy volunteers both young and elderly will be recruited through public announcements via the Relay for Information on Cognitive Sciences RISC from patients relatives or through the Fondation Recherche Alzheimer Participation of both patients and healthy individuals will be voluntary free and informed Participants will be contacted by phone or email by one of the study investigators They will be informed about the conduct and purpose of the research protocol
Protocol All participants will spend 3 days in the Sleep Disorders Unit of the Salpêtrière Hospital including two nights
Day 1 Participants will arrive in the late afternoon and will be fitted with the sensors required for video-polysomnography to monitor vigilance and sleep stages throughout the experiment Then they will 1 complete an attention task modified version of the Sustained Attention to Response Task SART 2 perform an associated memory task oldnew task consisting on recognition of words they have seen in the SART task and 3 their resting-state EEG activity will be recorded They will sleep in the laboratory night 1 without intervention
Day 2 Participants will retake the word recognition task the morning after night 1 During the afternoon they will fill different sleep questionnaires to assess their subjective feeling about their sleep Pittsburgh sleep quality index PSQI Epworth sleepiness scale and the REM Behavior Disorder Screening Questionnaire RBDSQ as well as the geriatric depression scale GDS In the late afternoon they will perform the learning and test phases of the visuospatial memory task They will then sleep in the laboratory night 2 with TMR During their slow-wave sleep half of the sounds associated with the items from the visuospatial memory task will be replayed
Day 3 Participants will once again perform the visuospatial memory test the morning after night 2
Aging is also associated with difficulties in maintaining daytime vigilance even after a period of rest impacting cognitive function including the encoding and retrieval of memories Interestingly recent studies have revealed the existence of sleep intrusions in the form of slow waves in wakefulness EEG recordings These have been associated with subjective and objective markers of fatigue predict transient lapses in attention and are particularly present after sleep deprivation the investigators believe that slow waves during both sleep and wakefulness could constitute a common biomarker of sleep disturbances and daytime vigilance problems A dysregulation of slow waves fewer during sleep more during wakefulness could thus explain the impact of aging on the three fundamental stages of the memory process encoding consolidation and retrieval Since alterations in memory capacity attention and sleep quality are further exacerbated in patients with Alzheimers disease AD the investigators propose to study the links between aging normal and pathological sleep and daytime vigilance alterations and their impacts on the different key stages of memory
Aims Our main objective is to test the associations between slow waves during sleep and wakefulness and the alterations in memory and vigilance during normal and pathological aging by studying young adults seniors without cognitive disorders and patients of the same age with prodromal AD
Additionally the investigators aim to test the efficiency of targeted memory reactivation TMR in older adults with and without cognitive deficits TMR is a technique that has been showed to boost memory consolidation in young adults and mice by replaying during sleep sensory cues that have been previously associated with the learning material
Methods Participants To do so the stydy will include three groups young adults 18-35 yo older adults without cognitive deficits 65-80 yo and older adults of the same age and with cognitive deficits patients with prodromal Alzheimers disease Prodromal stage of Alzheimers disease diagnosis will be performed by trained neurologists at the at the Memory and Alzheimers Disease Institute IM2A of the Pitié-Salpêtrière Hospital according to international diagnostic criteria as a clinical phenotype of progressive amnestic syndrome of the hippocampal type associated with biological markers of Alzheimers disease from lumbar puncture Aβ 600 pgmL and ptau 60 pgmL During their clinical follow-up at the IM2A patients diagnosed with prodromal AD will be offered the opportunity to participate in the study in agreement with their attending physician Healthy volunteers both young and elderly will be recruited through public announcements via the Relay for Information on Cognitive Sciences RISC from patients relatives or through the Fondation Recherche Alzheimer Participation of both patients and healthy individuals will be voluntary free and informed Participants will be contacted by phone or email by one of the study investigators They will be informed about the conduct and purpose of the research protocol
Protocol All participants will spend 3 days in the Sleep Disorders Unit of the Salpêtrière Hospital including two nights
Day 1 Participants will arrive in the late afternoon and will be fitted with the sensors required for video-polysomnography to monitor vigilance and sleep stages throughout the experiment Then they will 1 complete an attention task modified version of the Sustained Attention to Response Task SART 2 perform an associated memory task oldnew task consisting on recognition of words they have seen in the SART task and 3 their resting-state EEG activity will be recorded They will sleep in the laboratory night 1 without intervention
Day 2 Participants will retake the word recognition task the morning after night 1 During the afternoon they will fill different sleep questionnaires to assess their subjective feeling about their sleep Pittsburgh sleep quality index PSQI Epworth sleepiness scale and the REM Behavior Disorder Screening Questionnaire RBDSQ as well as the geriatric depression scale GDS In the late afternoon they will perform the learning and test phases of the visuospatial memory task They will then sleep in the laboratory night 2 with TMR During their slow-wave sleep half of the sounds associated with the items from the visuospatial memory task will be replayed
Day 3 Participants will once again perform the visuospatial memory test the morning after night 2
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None