Ignite Creation Date:
2024-07-17 @ 11:12 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06490822
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-08
First Post:
2024-06-25
Brief Title:
The Skin as a Window to the Central Nervous System in Frontotempolar Lombar Degeneration
Sponsor:
Nantes University Hospital
Organization:
Nantes University Hospital
Study Overview
Official Title:
The Skin as a Window to the Central Nervous System in Frontotempolar Lombar Degeneration
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PROTEINOSKIN
Brief Summary:
Frontotemporal lobar degeneration FTLD is a clinically heterogeneous syndrome characterized by progressive decline in behaviour andor language From a pathological standpoint like the great majority of neurodegenerative disorders FTLD are proteinopathies which are characterized by the presence of specific protein deposits in the Central Nervous System CNS Accordingly the two main deposits observed in FTLD are either made of Tau or transactive response DNA binding protein 43 TDP-43
In pathological conditions such as FTLD both proteins are aggregated and hyperphosphorylated
It is now well established that the pathological process in some proteinopathies such as synucleinopathies of which Parkinsons disease is the main representative is not limited to the brain but also widespread throughout the peripheral autonomic networks including the autonomic innervation of the skin In this context many independent studies have shown that the pathological process in PD could be detected using routine punch skin biopsies opening the way for the development of original histopathological markers of the disease
Our hypothesis is that such a scenario could also occur in FTLDs and that the detection of the pathological tau or TDP-43 protein in the skin could help in diagnosing FTLD This is especially relevant as despite the recent progress in genetics neurobiology and neuroimaging there are no available biomarkers for FTLD
In pathological conditions such as FTLD both proteins are aggregated and hyperphosphorylated
It is now well established that the pathological process in some proteinopathies such as synucleinopathies of which Parkinsons disease is the main representative is not limited to the brain but also widespread throughout the peripheral autonomic networks including the autonomic innervation of the skin In this context many independent studies have shown that the pathological process in PD could be detected using routine punch skin biopsies opening the way for the development of original histopathological markers of the disease
Our hypothesis is that such a scenario could also occur in FTLDs and that the detection of the pathological tau or TDP-43 protein in the skin could help in diagnosing FTLD This is especially relevant as despite the recent progress in genetics neurobiology and neuroimaging there are no available biomarkers for FTLD
Detailed Description:
Participant with Frontotemporal Lobar degeneration equally distributed into behavioral variant of frontotemporal dementia bvFTD language variant with primary progressive aphasia PPA and motor presentations with atypical parkinsonian disorders corticobasal degeneration-CBD and progressive supranuclear palsy-PSP and motoneuron disorder amyotrophic lateral sclerosis -ALS will be included at Nantes University Hospital during a period of 24 months
Healthy volunteers will be included as comparative group A skin biopsy and venous blood samples will be collected for all participants
Healthy volunteers will be included as comparative group A skin biopsy and venous blood samples will be collected for all participants
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None