Ignite Creation Date:
2024-07-17 @ 11:10 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06472427
Status:
COMPLETED
Last Update Posted:
2024-07-08
First Post:
2024-05-30
Brief Title:
The Effect of Butanediol Ingestion on Skeletal Muscle Angiogenesis in Hypoxia
Sponsor:
KU Leuven
Organization:
KU Leuven
Study Overview
Official Title:
The Acute Effect of R-13-butanediol Ingestion on Post-exercise Skeletal Muscle Angiogenesis in Healthy Adults Under Normoxic and Hypoxic Conditions
Status:
COMPLETED
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study specifically aims to elucidate the effects of intermittent exogenous ketosis IEK as well as hypoxia on muscular pro-angiogenic factors- after a 60-min HIIT bout in normoxia Moreover blood and muscle oxygenation status as well as peripheral blood flow and cognitive function will be assessed
Detailed Description:
After an exercise bout angiogenesis is incredibly important in the recovery process as an increased number of capillaries enables higher metabolite transport to and from the working muscle Often a training strategy consists of living-high sleeping at -stimulated- altitude and training low training at sea level A decreased oxygen availability also known as hypoxia however poses an additional stress on the human body potentially compromising the overall training efficiency Ketones are recently found to increase angiogenesis in response to overload training increased skeletal muscle capillarization and VEGF content and to increase serum EPO concentrations Therefore the investigators want to evaluate the isolated and interactive effects of both ketones and hypoxia on post-exercise recovery and factors implicated in skeletal muscle angiogenesis after training in normoxia Moreover a performance test will be performed after 7h of hypoxic or normoxic recovery by means of a simulated 15 min all-out time trial During the 7h post-exercise window biological samples are collected muscle biopsies venous blood samples urine capillary blood samples Moreover blood and muscle oxygenation peripheral blood flow and cognitive function are assessed at regular timepoints
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None