Ignite Creation Date:
2024-07-17 @ 11:06 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06466096
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-20
First Post:
2024-06-03
Brief Title:
Correlation Analysis of POD and pNCD in Elderly Patients With Gastrointestinal Neoplasms Based on Rs-fMRI
Sponsor:
Xuanwu Hospital Beijing
Organization:
Xuanwu Hospital Beijing
Study Overview
Official Title:
Correlation Analysis of Postoperative Delirium and Postoperative Neurocognitive Disorder in Elderly Patients With Gastrointestinal Neoplasms Based on Resting State Functional Magnetic Resonance Imaging
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This is a prospective cohort study to explore the differences of resting-state functional magnetic resonance imaging fMRI between elderly gastrointestinal neoplasms patients with postoperative delirium POD who either develop or do not develop long-term postoperative neurocognitive disorders pNCD
Detailed Description:
The purpose of this study is to explore the differences of resting-state functional magnetic resonance imaging fMRI between elderly gastrointestinal neoplasms patients with postoperative delirium POD who either develop or do not develop long-term postoperative neurocognitive disorders pNCD
Elderly gastrointestinal neoplasms patients aged 65 and above undergoing surgical operations at Xuanwu Hospital Capital Medical University were selected All patients underwent baseline fMRI scan before surgery and their neurocognitive function was assessed using the Montreal Cognitive Assessment MoCA within 1 week before surgery General patient data such as sex age comorbidities BMI ASA classification and MoCA scores were collected Under routine anesthetic management of the Department of Anesthesiology and Surgical Operations at Xuanwu Hospital endotracheal intubation general anesthesia was performed Intraoperative monitoring included heart rate blood pressure pulse oximetry and body temperature with surgery and anesthesia times and fluid balance recorded Within 7 days post-surgery delirium assessment was conducted using the Confusion Assessment Method CAM classifying patients into POD and non-POD groupsFor the patients in the POD group neurocognitive function was assessed at a period of time after surgery to determine the presence of pNCD further dividing the POD group into pNCD and non-pNCD subgroups followed by fMRI scanning Differences of FC in fMRI were compared between patients with POD who did or did not develop postoperative neurocognitive dysfunction By comparing the patterns and intensities of brain functional connectivity between the pNCD and non-pNCD subgroups a differential analysis was conducted on the effective connectivity and information flow of functional networks exploring the state of the brain functional network during the process of POD and pNCD
Elderly gastrointestinal neoplasms patients aged 65 and above undergoing surgical operations at Xuanwu Hospital Capital Medical University were selected All patients underwent baseline fMRI scan before surgery and their neurocognitive function was assessed using the Montreal Cognitive Assessment MoCA within 1 week before surgery General patient data such as sex age comorbidities BMI ASA classification and MoCA scores were collected Under routine anesthetic management of the Department of Anesthesiology and Surgical Operations at Xuanwu Hospital endotracheal intubation general anesthesia was performed Intraoperative monitoring included heart rate blood pressure pulse oximetry and body temperature with surgery and anesthesia times and fluid balance recorded Within 7 days post-surgery delirium assessment was conducted using the Confusion Assessment Method CAM classifying patients into POD and non-POD groupsFor the patients in the POD group neurocognitive function was assessed at a period of time after surgery to determine the presence of pNCD further dividing the POD group into pNCD and non-pNCD subgroups followed by fMRI scanning Differences of FC in fMRI were compared between patients with POD who did or did not develop postoperative neurocognitive dysfunction By comparing the patterns and intensities of brain functional connectivity between the pNCD and non-pNCD subgroups a differential analysis was conducted on the effective connectivity and information flow of functional networks exploring the state of the brain functional network during the process of POD and pNCD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None