Ignite Creation Date:
2024-07-17 @ 11:06 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06498726
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-12
First Post:
2024-07-07
Brief Title:
Role of Transcranial Doppler and Magnetic Resonance Angiography for Future Management of Sickle Cell Anemia CNS
Sponsor:
Eman Abdul-Hai
Organization:
Assiut University
Study Overview
Official Title:
Role of Transcranial Doppler and Magnetic Resonance Angiography for Future Management of Sickle Cell Anemia CNS
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aimed to determine the Predictive Value of Transcranial Doppler and Magnetic Resonance Angiography for Future Management of Sickle Cell Anemia
Specific aims are
Demonstrate silent parenchymal and vascular brain changes that are incidentally observed in neurologically free SCD children using screening TCD and MRA in Pediatric Hematology unit at Assiut University Hospital
Detect any abnormality with vasculopathy arterial occlusion and old SCI Strokes in children with SCD can be prevented by checking a transcranial Doppler TCD ultrasoundMRA and providing blood transfusions to children with abnormal blood flow on the TCD and detect Silent cerebral and cerebrovascular changes in SCD
Specific aims are
Demonstrate silent parenchymal and vascular brain changes that are incidentally observed in neurologically free SCD children using screening TCD and MRA in Pediatric Hematology unit at Assiut University Hospital
Detect any abnormality with vasculopathy arterial occlusion and old SCI Strokes in children with SCD can be prevented by checking a transcranial Doppler TCD ultrasoundMRA and providing blood transfusions to children with abnormal blood flow on the TCD and detect Silent cerebral and cerebrovascular changes in SCD
Detailed Description:
Cerebro-vascular accident is a destructive complication of sickle cell disease CVA is a important cause of morbidity and mortality individuals with SCD which cause motor and neurocognitive complications The CVA pathophysiology can be described by vasculopathy and obstruction caused by the sickle erythrocytes with narrowing of cerebral vessels of the circle of Willis middle cerebral artery anterior cerebral artery anterior communicating artery internal carotid artery posterior cerebral artery and posterior communicating artery
Patients with sickle cell disease develop vasculopathy and obstruction at specific sites as distal internal carotid artery ICA and the proximal segments of the middle cerebral artery MCA and anterior cerebral artery ACA This Study have been concerned to identify synchronous risk factors for Cerebro-vascular accident and the presence of increase in cerebral blood flow velocity CBFV in arterial parts of the polygon of Willis by transcranial doppler TCD has been confirmed as the important risk factor for the development of ischemic Cerebrovascular accidents in children and adolescents with SCA TCD can detect intracranial arterial narrowing caused by arterial vasculopathy associated with SCA TCD is a non-invasive portable and relatively inexpensive method that uses specific areas of the skull to access the intracranial arterial circulation and to measure CBFV in the polygon of Willis arteries magnetic resonance Angiography MRA and cerebral angiography are available for cerebrovascular disease diagnosis5-8 However TCD is due to its operator dependent it has a narrow application area Cerebrovascular disease indicates a group of disorders that alter the flow of blood in the brain The brains functions can be temporarily or permanently impaired as a result of this change in blood flow Timely diagnosis and treatment can restore the brain-impaired functions resulting in a much-improved prognosis for the patients This review summarizes the basic principles underlying the TCD imaging technique and its utility as a diagnostic tool for cerebrovascular disease
Patients with sickle cell disease develop vasculopathy and obstruction at specific sites as distal internal carotid artery ICA and the proximal segments of the middle cerebral artery MCA and anterior cerebral artery ACA This Study have been concerned to identify synchronous risk factors for Cerebro-vascular accident and the presence of increase in cerebral blood flow velocity CBFV in arterial parts of the polygon of Willis by transcranial doppler TCD has been confirmed as the important risk factor for the development of ischemic Cerebrovascular accidents in children and adolescents with SCA TCD can detect intracranial arterial narrowing caused by arterial vasculopathy associated with SCA TCD is a non-invasive portable and relatively inexpensive method that uses specific areas of the skull to access the intracranial arterial circulation and to measure CBFV in the polygon of Willis arteries magnetic resonance Angiography MRA and cerebral angiography are available for cerebrovascular disease diagnosis5-8 However TCD is due to its operator dependent it has a narrow application area Cerebrovascular disease indicates a group of disorders that alter the flow of blood in the brain The brains functions can be temporarily or permanently impaired as a result of this change in blood flow Timely diagnosis and treatment can restore the brain-impaired functions resulting in a much-improved prognosis for the patients This review summarizes the basic principles underlying the TCD imaging technique and its utility as a diagnostic tool for cerebrovascular disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None