Ignite Creation Date:
2024-07-17 @ 11:06 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06462313
Status:
RECRUITING
Last Update Posted:
2024-06-17
First Post:
2024-05-23
Brief Title:
Dobutamine for Management of Surgical Patients With Septic Shock
Sponsor:
First Affiliated Hospital of Zhejiang University
Organization:
First Affiliated Hospital of Zhejiang University
Study Overview
Official Title:
Director Head of Anesthesiology and Critical Care Principal Investigator Professor
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Septic shock is the last and most severe stage of sepsis and is defined by extremely low blood pressure despite lots of intravenous fluids The incidence of septic shock related cardiomyopathy was 10 to 70 Besides general anesthesia will inhibit the sympathetic nervous system reduce myocardial contractility and aggravate cardiac dysfunction No randomized controlled trials have yet explore the effects of dobutamine on clinical outcomes for patients with septic shock undergoing surgery under general anesthesia
Detailed Description:
Sepsis defined as life-threatening organ dysfunction is caused by a dysregulated host response to infection which 30-day mortality rate is about 244 Septic shock is the last and most severe stage of sepsis and is defined by extremely low blood pressure despite lots of intravenous fluids
Surgical patients with septic shock are not rare The incidence of septic shock related cardiomyopathy was 10 to 70 Besides general anesthesia will inhibit the sympathetic nervous system reduce myocardial contractility and aggravate cardiac dysfunction furthermore exacerbate hemodynamic instability and then increase the incidence of AKI and patient mortality Therefore to improve cardiac function in patients with septic shock who received general anesthesia is the key to save patients life and improve prognosis
The latest international guidelines for the treatment of septic shock recommend - in patients with septic shock combined with cardiac dysfunction treatment with norepinephrine in combination with dobutamine is recommended if inadequate tissue perfusion persists after adequate fluid resuscitation and maintenance of blood pressure but the level of evidence is weak
Dobutamine acts on β-adrenergic receptors which can improve tissue perfusion and small doses of 25-5ugkgmin can increase myocardial contractility and improve cardiac function in patients without increasing heart rate Previous study has demonstrated that the combined use of norepinephrine and dobutamine can elevate left ventricular ejection fraction cardiac index improve tissue perfusion and reduce mortality in patients with septic shock No randomized controlled trials have yet explore the effects of dobutamine on clinical outcomes for patients with septic shock undergoing surgery under general anesthesia
Surgical patients with septic shock are not rare The incidence of septic shock related cardiomyopathy was 10 to 70 Besides general anesthesia will inhibit the sympathetic nervous system reduce myocardial contractility and aggravate cardiac dysfunction furthermore exacerbate hemodynamic instability and then increase the incidence of AKI and patient mortality Therefore to improve cardiac function in patients with septic shock who received general anesthesia is the key to save patients life and improve prognosis
The latest international guidelines for the treatment of septic shock recommend - in patients with septic shock combined with cardiac dysfunction treatment with norepinephrine in combination with dobutamine is recommended if inadequate tissue perfusion persists after adequate fluid resuscitation and maintenance of blood pressure but the level of evidence is weak
Dobutamine acts on β-adrenergic receptors which can improve tissue perfusion and small doses of 25-5ugkgmin can increase myocardial contractility and improve cardiac function in patients without increasing heart rate Previous study has demonstrated that the combined use of norepinephrine and dobutamine can elevate left ventricular ejection fraction cardiac index improve tissue perfusion and reduce mortality in patients with septic shock No randomized controlled trials have yet explore the effects of dobutamine on clinical outcomes for patients with septic shock undergoing surgery under general anesthesia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None