Ignite Creation Date:
2024-07-17 @ 11:05 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06471179
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-24
First Post:
2024-06-18
Brief Title:
Functional Magnetic Resonance Imaging Study in Schizophrenia Patients and Correlation With Cognitive Impairments
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Functional Magnetic Resonance Imaging Study of Schizophrenic Patients and Its Correlation With Cognitive Impairments
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 Comparison of functional activity at different brain areas related to different cognitive domains eg Memory visuospatial abilities executive functions attention concentration language orientation in schizophrenia to healthy subjects
2 Correlation with resting functional activity at brain areas with clinical deterioration in cognitive functions
2 Correlation with resting functional activity at brain areas with clinical deterioration in cognitive functions
Detailed Description:
Schizophrenia represents a multifaceted clinical challenge Patients outcome is still highly heterogeneous and poor Cognitive impairment a central feature of the illness is present in over 80 of patients with schizophrenia is a main functional disability Currently available antipsychotics have only limited effects on cognition and side effects may even aggravate some deficits So far pharmacological options for cognitive deficits in schizophrenia are unsatisfactory due to either limited efficacy or tolerability concerns Understanding the quality quantity of brain changes could cover patterns of potential therapeutic relevance guiding treatments Understanding the pathophysiology of impaired cognition in schizophrenia and developing effective treatment for cognitive symptoms are major unmet challenges for contemporary biomedical research Briefly deficits in speed of processing have been correlated with a reduced temporal lobe volume and increased ventricular size Attention impairments were correlated with structural alterations within the frontal and temporal lobes and with widespread reduced volume of subcortical regions Decreased working memory was correlated with reduced frontal and temporal lobe volumes and cortical thickness while language and memory deficits were correlated with hippocampal volume loss Impaired visuspatial and memory correlated with hippocampal volume loss Deficits in reasoning and problem solving including higher-order executive functions were also associated with a reduced the dorsolateral prefrontal cortex volume Among different neuroimaging modalities functional magnetic resonance imaging fMRI predominates in system-level connectomic studies Particularly the task-free version-known as resting fMRI-is better tolerated by clinical populations and circumvents the need for stringent subject compliance Today fMRI features are being rigorously examined to identify potential biomarkers for diagnosis and prognosis of different brain disorders
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None