Ignite Creation Date:
2024-07-17 @ 11:01 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06463964
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-06-18
First Post:
2024-06-04
Brief Title:
Predictors of Acute Kidney Injury in Patients With Acute Decompensated Heart Failure in Emergency
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Predictors of Acute Kidney Injury in Patients With Acute Decompensated Heart Failure in Emergency
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Acute Decompensated Heart Failure ADHF is one of the leading causes of hospitalization ADHF is a growing global health problem affecting more than 26 million individuals worldwide Acute Kidney Injury AKI is a common event in the natural disease history of patients with Heart Failure HF The clinical importance of the co-existence of acute cardiac and renal dysfunction known as acute cardiorenal syndrome CRS and its management have recieved great attention recently Various studies have employed different criteria to define and calssify AKI According to Risk Injury and Failure and Loss and End-stage kidney disease RIFLE criteria formulated by the Acute Dialyisis Quality Initiative ADQI AKI can be divided into five stages renal injury risk renal impairment renal failure renal function loss and end stage kidney disease
Detailed Description:
In the past few years investigators have reported that AHF patients might experience congestion named to describe signs and symptoms of extracellular fluid accumulation that results in increased cardiac filling pressure This triggers compensatory mechanisms such as the renin-angiotensin-aldosterone system sympathetic nervous system and other local mediators These compensatory mechanisms interact to maintain fluid volume and renal congestion has been recognized as part of systemic congestion Renal congestion resulting from lower cardiac output tubule glomerular feedback increased intra-abdominal pressure and increased venous pressure has been viewed as a contributor to renal function impairment in ADHF
Most patients with acute CRS are treated in the emergency department ED The findings provide important insight into the present situation of patients with ADHF who develop AKI in an emergency setting
The current diagnostic paradigm for AKI relies largely on biomarkers of renal function serum creatinine and urine output that have been in clinical use for over 50 years but are known to be insensitive and slow to change after kidney injury It is very important to detect kidney damage in the preclinical process with new diagnostic methods and thus to provide early intervention in AKI
Changing AKI definition and classification by year these existing prediction models also vary by population region sample size and research methods However many studies have found a high incidence of AKI and a large impact on outcomes in ADHF patients data pooled from these studies are inadequate So we will conduct this study to evaluate predictors of AKI in patients with ADHF in emergency departments
Most patients with acute CRS are treated in the emergency department ED The findings provide important insight into the present situation of patients with ADHF who develop AKI in an emergency setting
The current diagnostic paradigm for AKI relies largely on biomarkers of renal function serum creatinine and urine output that have been in clinical use for over 50 years but are known to be insensitive and slow to change after kidney injury It is very important to detect kidney damage in the preclinical process with new diagnostic methods and thus to provide early intervention in AKI
Changing AKI definition and classification by year these existing prediction models also vary by population region sample size and research methods However many studies have found a high incidence of AKI and a large impact on outcomes in ADHF patients data pooled from these studies are inadequate So we will conduct this study to evaluate predictors of AKI in patients with ADHF in emergency departments
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None