Ignite Creation Date:
2024-07-17 @ 10:52 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06473285
Status:
RECRUITING
Last Update Posted:
2024-06-25
First Post:
2024-05-27
Brief Title:
Effects of Esketamine on Consciousness-related Brain Network Characteristics in Patients With Prolonged Disorders of Consciousness
Sponsor:
Beijing Tiantan Hospital
Organization:
Beijing Tiantan Hospital
Study Overview
Official Title:
Effects of Esketamine on Consciousness-related Brain Network Characteristics in Patients With Prolonged Disorders of Consciousness
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Prolonged disorders of consciousness pDoC are pathologies in which there is a loss of consciousness for more than 28 days The number of patients with pDoC is increasing as the level of critical care treatment and monitoring improves However clinical trials for patients with pDoC are limited by small sample sizes lack of placebo groups and use of heterogeneous outcome measures As a result few therapies have strong evidence to support their use In recent years ketamine has been used with remarkable success in the treatment of neuropsychiatric disorders by inducing neuroplasticity increasing neurophysiologic complexity and expanding functional brain connectivity states Considering increased brain plasticity as well as brain complexity it may be beneficial for consciousness recovery In this study the investigators aimed to explore the effects of esketamine on brain networks and level of consciousness in patients with pDoC and to discuss its possible use as a wakefulness-promoting treatment for patients with pDoC
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None