Ignite Creation Date:
2024-07-17 @ 10:51 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06469333
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-21
First Post:
2024-06-05
Brief Title:
Theories of Working Memory and ConsolidationRECOnsolidation in the Process of Resorption of Post-traumatic Symptoms
Sponsor:
University of Lorraine
Organization:
University of Lorraine
Study Overview
Official Title:
Theories of Working Memory and ConsolidationRECOnsolidation in the Process of Resorption of Certain Post-traumatic Symptoms Interventional Randomized Single-center Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
EMDR is a psychotherapeutic approach recommended by the World Health Organization WHO for the treatment of disorders such as post-traumatic stress disorder anxiety depression and more generally psychological distress In all these disorders intrusions are one of the symptoms leading to intense emotional distress EMDR therapy by making intrusions less emotional and less present in the mind ie less vivid would reduce psychological distress This symptomatological reduction would be made possible by the therapists application of alternating bilateral visual rapid eye movements following a point from left to right auditory tones emitted alternately in the right ear and then in the left ear andor tactile tapping with fingers on the left and right shoulders alternately stimulations administered while the patient concentrates on his or her intrusive thoughts Accordingly the aim of this research is to investigate the efficacy of self-administration of Alternating Bilateral Stimulations ABS on the emotional intensity emotionality associated with negative intrusive thoughts or intrusions
Detailed Description:
Intrusive thoughts or intrusions are recognized as being particularly vivid and emotionally charged and constitute one of the transdiagnostic symptoms of numerous disorders such as Post Traumatic Stress Disorder PTSD anxiety and depression
Numerous studies have demonstrated that it is now possible to modulate the persistence of intrusions in memory as well as their emotional impact through Eye Movement Desensitization and Reprocessing EMDR therapy EMDR is based on the administration of visual auditory sound or sensory tapping Alternating Bilateral Stimulations ABS These ABS which can be self-administered by the patient during the Memory Activation MA of an intrusive thought would reduce the emotionality and vividness of the intrusive symptoms and decrease the associated physiological reactivity
Recent research claims that the mechanisms of action of ABS involve a joint articulation of both neurobiological Memory ConsolidationReconsolidation M-CR and psychological Working Memory WM theories
Memory consolidation refers to the transfer of a newly acquired memory trace into WM fragile and susceptible to forgetting and its stabilization in Long-Term Memory LTM Consolidation involves two processes The first synaptic consolidation requires the triggering of molecular processes operating within a time window of between 10 minutes and 6 hours The second called systemic consolidation can extend over years and takes place mainly during the sleep cycle Reconsolidation implies that an intrusion when activated in WM becomes labile again and must subsequently be consolidated again reconsolidated in LTM A permanent memory can thus be revived then degraded notably by the administration of ABS likely to interfere with its reconsolidation in memory
Working memory WM refers to a memory system that enables the temporary retention and processing of information needed to perform complex cognitive tasks capacity is limited In fact the competition of two simultaneous tasks eg BAS administration during the memory activation MA of an intrusive thought implies in a consequential way an alteration in its storage performance as well as a decrease in the emotional load associated with the intrusion In other words while WM remains the strongest lead to date it can only be considered in conjunction with M-CR theory
From a clinicalexperimental protocol point of view this link implies compliance with a number of criteria The first is the temporal criterion for ABS administration between 10 minutes and 6 hours post-MA as well as the quantitative criterion relating to the number of MAs not to exceed 4 MAs In other words the application of an interventional methodology that does not meet all these criteria ie administration of ABS performed outside the M-CR time window and repeated MA of the same intrusion would induce the involvement of a third process namely the extinction process In one study the application of an extinction protocol performed within the consolidation window a paradigm known as Retrieval Extinction P-RE also induced a modification of the initial memory trace It would therefore seem appropriate to consider the adoption of a tri-processual integrative model involving the joint articulation of Working Memory WM Memory ConsolidationReconsolidation CR-M and the Retrieval Extinction Paradigm P-RE This is why we propose to study in this research the role of the application of this tri-processual theoretical modeling on the emotionality and vividness associated with intrusions as well as on their psychophysiological and psychopathological consequences Through the use of new technologies these methodologies could complement conventional psychotherapeutic treatments which through the self-administration of ABS could add up and in fact potentiate the effectiveness of psychotherapy
Numerous studies have demonstrated that it is now possible to modulate the persistence of intrusions in memory as well as their emotional impact through Eye Movement Desensitization and Reprocessing EMDR therapy EMDR is based on the administration of visual auditory sound or sensory tapping Alternating Bilateral Stimulations ABS These ABS which can be self-administered by the patient during the Memory Activation MA of an intrusive thought would reduce the emotionality and vividness of the intrusive symptoms and decrease the associated physiological reactivity
Recent research claims that the mechanisms of action of ABS involve a joint articulation of both neurobiological Memory ConsolidationReconsolidation M-CR and psychological Working Memory WM theories
Memory consolidation refers to the transfer of a newly acquired memory trace into WM fragile and susceptible to forgetting and its stabilization in Long-Term Memory LTM Consolidation involves two processes The first synaptic consolidation requires the triggering of molecular processes operating within a time window of between 10 minutes and 6 hours The second called systemic consolidation can extend over years and takes place mainly during the sleep cycle Reconsolidation implies that an intrusion when activated in WM becomes labile again and must subsequently be consolidated again reconsolidated in LTM A permanent memory can thus be revived then degraded notably by the administration of ABS likely to interfere with its reconsolidation in memory
Working memory WM refers to a memory system that enables the temporary retention and processing of information needed to perform complex cognitive tasks capacity is limited In fact the competition of two simultaneous tasks eg BAS administration during the memory activation MA of an intrusive thought implies in a consequential way an alteration in its storage performance as well as a decrease in the emotional load associated with the intrusion In other words while WM remains the strongest lead to date it can only be considered in conjunction with M-CR theory
From a clinicalexperimental protocol point of view this link implies compliance with a number of criteria The first is the temporal criterion for ABS administration between 10 minutes and 6 hours post-MA as well as the quantitative criterion relating to the number of MAs not to exceed 4 MAs In other words the application of an interventional methodology that does not meet all these criteria ie administration of ABS performed outside the M-CR time window and repeated MA of the same intrusion would induce the involvement of a third process namely the extinction process In one study the application of an extinction protocol performed within the consolidation window a paradigm known as Retrieval Extinction P-RE also induced a modification of the initial memory trace It would therefore seem appropriate to consider the adoption of a tri-processual integrative model involving the joint articulation of Working Memory WM Memory ConsolidationReconsolidation CR-M and the Retrieval Extinction Paradigm P-RE This is why we propose to study in this research the role of the application of this tri-processual theoretical modeling on the emotionality and vividness associated with intrusions as well as on their psychophysiological and psychopathological consequences Through the use of new technologies these methodologies could complement conventional psychotherapeutic treatments which through the self-administration of ABS could add up and in fact potentiate the effectiveness of psychotherapy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None