Ignite Creation Date:
2024-07-17 @ 10:48 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06498063
Status:
RECRUITING
Last Update Posted:
2024-07-12
First Post:
2024-02-22
Brief Title:
The Underlying Mechanisms Regarding the Effect of Glucagon on the Kidneys Will be Investigated in Healthy Males
Sponsor:
Ali Asmar
Organization:
Bispebjerg Hospital
Study Overview
Official Title:
Renal Extraction of Glucagon and Renal Effects of Glucagon
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this crossover study is to investigate to what extend glucagon affects the kidneys The main questions it aims to answer are
Does glucagon regulate kidney function through extraction in the kidney in addition to glomerular filtration Does glucagon regulate kidney function by increasing renal plasma flow and glomerular filtration rate Does glucagon regulate kidney function by increasing renal salt excretion
Does glucagon regulate kidney function through extraction in the kidney in addition to glomerular filtration Does glucagon regulate kidney function by increasing renal plasma flow and glomerular filtration rate Does glucagon regulate kidney function by increasing renal salt excretion
Detailed Description:
In patients with type 2 diabetes mellitus plasma concentrations of glucagon are inappropriately high hyperglucagonemia Hyperglucagonemia has been speculated to contribute to the pathophysiology of diabetic kidney disease Previously glucagon has been assumed to cause glomerular hyperfiltration associated with urinary excretion of small proteins a characteristic of early type 2 diabetic kidney injury Further glucagon has been shown to acutely increase urinary excretion of urea sodium and potassium and patients with end-stage renal disease have elevated plasma levels of glucagon
The purpose of this study is to clarify the underlying mechanisms behind the physiological effects of glucagon on kidney function and the kidneys ability to clear glucagon from the blood in healthy males Specifically the investigators aim to answer the following questions
Does glucagon regulate kidney function through extraction in the kidney in addition to glomerular filtration Does glucagon regulate kidney function by increasing renal plasma flow and glomerular filtration rate Does glucagon regulate kidney function by increasing renal salt excretion
The renal extraction of glucagon and the renal effects of glucagon will be investigated during a constant glucagon infusion in 10 healthy men aged 20-60 years The study will be placebo-controlled Each subject will participate in three independent and randomized trial days with a washout period of at least four weeks
The purpose of this study is to clarify the underlying mechanisms behind the physiological effects of glucagon on kidney function and the kidneys ability to clear glucagon from the blood in healthy males Specifically the investigators aim to answer the following questions
Does glucagon regulate kidney function through extraction in the kidney in addition to glomerular filtration Does glucagon regulate kidney function by increasing renal plasma flow and glomerular filtration rate Does glucagon regulate kidney function by increasing renal salt excretion
The renal extraction of glucagon and the renal effects of glucagon will be investigated during a constant glucagon infusion in 10 healthy men aged 20-60 years The study will be placebo-controlled Each subject will participate in three independent and randomized trial days with a washout period of at least four weeks
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 20-1914 21-1518 | OTHER_GRANT | None | None |
| NNF21OC0070308 | OTHER_GRANT | None | None |