Ignite Creation Date:
2024-07-17 @ 10:48 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06490003
Status:
RECRUITING
Last Update Posted:
2024-07-08
First Post:
2024-06-21
Brief Title:
Predicting Postoperative Chemotherapy Efficacy in Patients With Esophageal Squamous Cell Carcinoma
Sponsor:
City of Hope Medical Center
Organization:
City of Hope Medical Center
Study Overview
Official Title:
Predicting Postoperative Chemotherapy Efficacy in Patients With Esophageal Squamous Cell Carcinoma by Biopsy Specimens
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Esophageal cancer remains a disease with a poor prognosis Chemotherapy is an important part of its treatment but there are cases in which chemotherapy is ineffective The investigators aim to develop a model to predict the response to chemotherapy by DNA methylation of preoperative biopsy specimens to identify the chemotherapy ineffective group
Detailed Description:
Esophageal cancer remains a disease with a poor prognosis In the treatment of esophageal squamous cell carcinoma ESCC multidisciplinary treatment including surgery chemotherapy and radiation therapy is important Chemotherapy is an effective treatment for esophageal cancer but some patients do not respond to it Non-response to chemotherapy can result in disease progression loss of patient fitness and even the opportunity to receive other treatments that might have originally had a therapeutic effect If there are biomarkers that could indicate the efficacy of chemotherapy before treatment ineffective patients would be able to change their treatment plan Patients on preoperative chemotherapy would be able to avoid unnecessary chemotherapy and undergo surgery without the effects of physical weakness and side effects On the other hand patients on definitive chemotherapy may choose to intensify their treatment with additional radiation therapy or immunotherapy The investigators aim to develop a model to predict the response to chemotherapy by DNA methylation of preoperative biopsy specimens to identify the chemotherapy ineffective
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None