Ignite Creation Date:
2024-07-17 @ 10:43 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06481059
Status:
COMPLETED
Last Update Posted:
2024-07-01
First Post:
2024-06-22
Brief Title:
suPAR is a Potential Biomarker of in Chronic Periodontitis Through the Impact of Post-radiotherapy on HNCs Patients
Sponsor:
Al-Maarif University College
Organization:
Al-Maarif University College
Study Overview
Official Title:
Soluble Urokinase Plasminogen Activator Receptor suPAR is a Potential Biomarker of Stage III-IV Grade C Periodontitis Through the Impact of Post-radiotherapy on Head and Neck Cancer Patients
Status:
COMPLETED
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HNCs
Brief Summary:
This study aims to improve a soluble urokinase plasminogen activator receptor suPAR is a reliable biomarker of chronic periodontitis and may be replaced in patients with head and neck cancer post-radiotherapy HNC post-RT
Detailed Description:
The urokinase-type plasminogen activator receptor uPAR plays an essential function in leukocytes and endothelial homeostasis and therefore in the development of chronic periodontitis The study enrolled 150 participants 50 chronic periodontitis with head and neck cancer post radiotherapy CPHNC post-RT patients 50 chronic periodontitis CP without HNC patients and 50 healthy controls Clinical Attachment Loss CAL Probing Pocket Depth PPD Plaque Index PI and Gingival Bleeding Index GBI were recorded An enzyme-linked immunosorbent assay ELISA was constructed to quantify serum suPAR levels Stage and grade of periodontitis were stage III-IV grade C in patients CPHNC post-RT stage I-III grade AB in patients CP without HNC and absent in healthy Chronic periodontitis with HNC post-RT patients presented a significantly higher proportion of suPAR levels 5067 pgml compared to chronic periodontitis without HNC and healthy controls 42308 pgml and 2559 pgml respectively A significant positive correlation was found between serum suPAR levels and CAL PPD PI and GBI in the periodontal disease groups ROC results of suPAR AUC0976 for CPHNC post-RT AUC0872 for CP without HNC Hyposalivation appeared in patients CPHNC post-RT 015 011-023 mlmin P0001 and CP without HNC 030 025-041 mlmin P0001 compared to healthy controls 035 028- 054 mlmin P0001 The study showed a significant elevation in serum suPAR levels in CPHNC post-RT patients compared to the CP without HNC and control groups
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None