Ignite Creation Date:
2024-06-16 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06460077
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-06-14
First Post:
2024-06-10
Brief Title:
Exploring Pathology Related to Slowly Expanding Lesions Using Advanced Imaging
Sponsor:
Turku University Hospital
Organization:
Turku University Hospital
Study Overview
Official Title:
Exploring Pathology Related to Slowly Expanding Lesions Using Advanced Imaging
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
SELPET
Brief Summary:
This is an open follow-up study to compare the performance of three critical imaging methods to detect chronic active lesions in MS in vivo
Detailed Description:
Smoldering inflammation is recognized as a critical contributor to MS progression-related CNS damage Activated microglia and macrophages particularly at chronic lesion edge are believed to promote lesion growth Reversing their harmful activity may prove to be an efficient way to halt progression independent of relapses in MS
These smoldering or chronic active lesions can be detected in vivo using advanced imaging techniques 1 Specific algorithms can be used to identify lesion growth with a hypothesis that the slowly evolving lesions SEL are the ones harboring a rim of activated microglial cells which contribute to damage in the surrounding tissue and lesion growth 2 Lesions partially or entirely surrounded by rims of increased tissue intensity on QSM-MRI quantitative susceptibility mapping sequences are considered as iron rim lesions with iron-containing proinflammatory microgliamacrophages at the lesion edge 3 In addition TSPO-PET imaging can be used to identify chronic active lesions based on TSPO-expression by activated innate immune cells and their gathering at the edges of chronic active lesions The TSPO-PET analysis of chronic active lesions can be semi-automated and the specific radioligand binding at the chronic active lesion edge can be quantitated which enhances the sensitivity of this method
Despite existing preliminary data demonstrating increased QSM signal TSPO-positive lesions it is yet to be demonstrated how these three imaging methods perform in identifying chronic active lesions when compared to each other at larger scale
These smoldering or chronic active lesions can be detected in vivo using advanced imaging techniques 1 Specific algorithms can be used to identify lesion growth with a hypothesis that the slowly evolving lesions SEL are the ones harboring a rim of activated microglial cells which contribute to damage in the surrounding tissue and lesion growth 2 Lesions partially or entirely surrounded by rims of increased tissue intensity on QSM-MRI quantitative susceptibility mapping sequences are considered as iron rim lesions with iron-containing proinflammatory microgliamacrophages at the lesion edge 3 In addition TSPO-PET imaging can be used to identify chronic active lesions based on TSPO-expression by activated innate immune cells and their gathering at the edges of chronic active lesions The TSPO-PET analysis of chronic active lesions can be semi-automated and the specific radioligand binding at the chronic active lesion edge can be quantitated which enhances the sensitivity of this method
Despite existing preliminary data demonstrating increased QSM signal TSPO-positive lesions it is yet to be demonstrated how these three imaging methods perform in identifying chronic active lesions when compared to each other at larger scale
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None