Ignite Creation Date:
2024-06-16 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06454838
Status:
RECRUITING
Last Update Posted:
2024-06-12
First Post:
2024-05-20
Brief Title:
Exercise Capacity Muscle Oxygenation and Arterial Stiffness in Children With Pulmonary Arterial Hypertension
Sponsor:
Gazi University
Organization:
Gazi University
Study Overview
Official Title:
Exercise Capacity Muscle Oxygenation and Arterial Stiffness in Children With Pulmonary Arterial Hypertension
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The primary aim is to evaluate pulmonary function respiratory muscle strength upper and lower extremity exercise capacity muscle oxygenation dyspnea peripheral muscle strength arterial stiffness physical activity level and balance in children with pulmonary arterial hypertension and compare with age- and sex-matched healthy controls
The second aim is to investigate the relationship between upper extremity exercise capacity arterial stiffness respiratory and peripheral muscle strength
The second aim is to investigate the relationship between upper extremity exercise capacity arterial stiffness respiratory and peripheral muscle strength
Detailed Description:
Pulmonary arterial hypertension PAH is defined as higher than 25 mmHg in mean pulmonary arterial pressure at rest Pulmonary arterial hypertension is chronic and progressive disease
Symptoms such as dyspnea fatigue exercise intolerance cyanosis and syncope are shown in children with PAH Most common symptom is dyspnea during exertion Dyspnea at rest could occur while the severity of disease is progressed All these symptoms have been associated with decreased cardiac output and mismatch oxygen transport
This study is planned as a cross-sectional study At least 13 children with PAH and at least 13 age- and sex- matched healthy controls will be included in this study Individuals pulmonary function spirometer respiratory muscle strength mouth pressure device upper extremity exercise capacity the six minute Peg Board Ring Test lower extremity exercise capacity six minute walk test muscle oxygenation Moxy monitor device dyspnea modified Borg Scale peripheral muscle strength hand-held dynamometer arterial stiffness arteriograph device physical activity level multi-sensor activity monitor and static balance balance system with computed will evaluated in children with PAH and healthy controls All assessments will be completed in two days
Symptoms such as dyspnea fatigue exercise intolerance cyanosis and syncope are shown in children with PAH Most common symptom is dyspnea during exertion Dyspnea at rest could occur while the severity of disease is progressed All these symptoms have been associated with decreased cardiac output and mismatch oxygen transport
This study is planned as a cross-sectional study At least 13 children with PAH and at least 13 age- and sex- matched healthy controls will be included in this study Individuals pulmonary function spirometer respiratory muscle strength mouth pressure device upper extremity exercise capacity the six minute Peg Board Ring Test lower extremity exercise capacity six minute walk test muscle oxygenation Moxy monitor device dyspnea modified Borg Scale peripheral muscle strength hand-held dynamometer arterial stiffness arteriograph device physical activity level multi-sensor activity monitor and static balance balance system with computed will evaluated in children with PAH and healthy controls All assessments will be completed in two days
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None