Ignite Creation Date:
2024-06-16 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06459323
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-14
First Post:
2024-05-15
Brief Title:
the Outcomes of Laparoscopic Cholecystectomy for Acute Cholecystitis Within and Beyond the First 72 Hours Does it Differ
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
the Outcomes of Laparoscopic Cholecystectomy for Acute Cholecystitis Within and Beyond the First 72 Hours Does it Differ
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Compare outcomes of patients undergoing early laparoscopic cholecystectomy within and after72 hours of symptoms
Detailed Description:
Laparoscopic cholecystectomy LC is the mainstay treatment of acute cholecystitis However it remains a challenging procedure with low but significant risks of major complications such as bile duct injury increasing as the severity of AC progresses New Guidelines suggest that laparoscopic cholecystectomy should preferably be performed within 72 hrs of symptom onset but has acknowledged that this may not be always possible in practice Hence it recommends that patients presenting after 72 h of symptom onset may still benefit from laparoscopic cholecystectomy in selected patients Studies found that it is imperative to convert to open cholecystectomy when it is deemed unsafe to dissect the Calots triangle may occur even within or beyond first 72 hrs of attck symptoms studies found a statistically longer mean total length of hospitalization operation time and intraoperative blood loss for LC performed beyond 72 h this did not translate into clinically significant adverse outcomes such as an increase in perioperative morbidity or the need for blood transfusion After 72 h chronic inflammation and fibrosis set in resulting in more technically demanding and longer surgeriesStudies show differing results reporting longer operation times for laparoscopic cholecystectomy beyond 72 h due to stiffer tissues that cannot be bluntly dissected during the subacute phase of tissue inflammation However other studies did not report any difference in operation times between both groups
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None