Ignite Creation Date:
2024-06-16 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06459037
Status:
RECRUITING
Last Update Posted:
2024-06-14
First Post:
2024-06-10
Brief Title:
Comparison of Salivary Neuropilin-1 NRP-1 Cotinine and C-Reactive Protein CRP Levels With Periodontal Clinical Parameters in Smokers and Non-Smokers With Different Periodontal Diseases
Sponsor:
Izmir Katip Celebi University
Organization:
Izmir Katip Celebi University
Study Overview
Official Title:
Comparison of Salivary Neuropilin-1 NRP-1 Cotinine and C-Reactive Protein CRP Levels With Periodontal Clinical Parameters in Smokers and Non-Smokers With Different Periodontal Diseases
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In order to determine the pathogenesis of chronic inflammatory diseases the levels of various cytokines are analysed in tissues and fluids taken from the body In various publications the role of the glycoprotein sNRP-1 on inflammatory diseases and the relationship between smoking and periodontal diseases have been investigated In this study our aim was to evaluate the levels of this biomarker in the saliva of smokers with systemically healthy periodontitis and non-smokers with systemically healthy periodontitis gingivitis and periodontal disease and to compare the concentration differences with CRP Another aim is to show the effect of nicotine exposure rate on all these by measuring cotinine levels In our study all oral clinical parameters of 80 patients including 20 systemically healthy non-smoking and periodontally healthy patients 20 patients with gingivitis 20 patients with periodontitis 20 systemically healthy smoking patients with periodontitis will be measured and saliva samples will be taken from the patients The sNRP-1 cotinine and CRP levels in the samples will be determined by enzyme-linked immunoassay ELISA Then statistical analyses will be performed and the difference in the levels of biomarkers between the groups will be interpreted Possible significant differences between the levels of these biomarkers may reveal that sNRP-1 can be used as a diagnostic tool in periodontal diseases or as a guide for treatments to be performed and may reveal a new perspective on the relationship between periodontitis and smoking
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None