Ignite Creation Date:
2024-06-16 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06457334
Status:
RECRUITING
Last Update Posted:
2024-06-13
First Post:
2024-05-27
Brief Title:
Effect of Helicobacter Pylori Eradication on Gastroesophageal RefIux Disease GERD
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Effect of Helicobacter Pylori Eradication on Gastroesophageal RefIux Disease GERD
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Evaluate the effect of Hpylori eradication on Gastroesophageal-reflux disease and symptoms improvement
Detailed Description:
HeIicobacter PyIori HpyIori is a gram-negative spiral shaped bacterium that affects up to 50 of the population worldwide with a higher prevalences in the developing countriesGastroesophageal reflux disease GERD is a chronic gastrointestinal disorder characterized by the regurgitation of gastric contents into the esophagus resulting in a significant economic burden in direct and indirect costs and adversely affects the quality of lifeGERD is caused by multiple different mechanisms that can be intrinsic structural or both leading to the disruption of the esophago-gastric junction barrier resulting in exposure of the esophagus to acidic gastric contents Clinically GERD typically manifests with symptoms of heartburn and regurgitation It can also present in an atypical fashion with extra-esophageal symptoms such as chest pain dental erosions chronic cough laryngitis or asthmaThe relationship between H pylori and gastroesophageal reflux disease GERD is still unclear and the effect of H pylori eradication on GERD treatment is unknownSeveral studies have shown the inverse relationship between the occurrence of GERD and HpyIori infection in particular an increased severity of the disease is documented in patients with pre-existing symptoms It has been showed that a markedly resolution of dyspepsia in patients at whom the eradication therapy was successful when compared with subjects with a persistent infection
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None