Ignite Creation Date:
2024-06-16 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06456437
Status:
RECRUITING
Last Update Posted:
2024-06-13
First Post:
2024-05-30
Brief Title:
Ischemic Post-conditioning in the Treatment of Acute Ischemic Stroke
Sponsor:
Ming Wei
Organization:
Tianjin Huanhu Hospital
Study Overview
Official Title:
Ischemic Post-conditioning in the Treatment of Acute Ischemic Stroke--a Multicenter Prospective Cohort Study
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Post-ischemic adaptation is a physical brain protective treatment strategy in which an ischemic event in an organ or tissue is treated and blood flow is restored and an ischemic stimulus is given to local tissues to induce the production of anti-ischemic damage factors and reduce the damage associated with reperfusion therapy Relevant basic studies have confirmed that post-ischemic adaptation can reduce infarct volume and promote neurological function recovery in animal models of cerebral infarction Therefore it may be beneficial to the recovery of neurological function in patients with acute ischemic stroke undergoing mechanical thrombus extraction
Based on the above background the use of a balloon to repeatedly dilate-contract at the original occlusion site after revascularization to block and restore arterial flow may be an effective cerebroprotective treatment for patients with large-vessel occlusion who undergo thrombolysis However can this approach be safely used in patients with acute ischemic stroke treated with thrombolysis What is the protocol for the length of time patients can tolerate post-ischemic adaptation The application of this method in the treatment of acute ischemic stroke will be explored in this study
Based on the above background the use of a balloon to repeatedly dilate-contract at the original occlusion site after revascularization to block and restore arterial flow may be an effective cerebroprotective treatment for patients with large-vessel occlusion who undergo thrombolysis However can this approach be safely used in patients with acute ischemic stroke treated with thrombolysis What is the protocol for the length of time patients can tolerate post-ischemic adaptation The application of this method in the treatment of acute ischemic stroke will be explored in this study
Detailed Description:
Stroke has become the second leading cause of death in the world and the first cause of death and disability in adults in China among them ischemic stroke AIS accounts for about 80 of all strokes and is the most important type of stroke Ischemic stroke is usually caused by acute occlusion of cerebral blood vessels therefore opening the occluded blood vessels is the key to its treatment at present intravenous thrombolysis and endovascular mechanical thrombolysis are recommended by domestic and international guidelines for recanalization of blood vessels and they have become the most effective treatment measures for ischemic stroke However due to the short therapeutic time window 45 hours and low recanalization rate of large vessel occlusion less than 20 of intravenous thrombolysis endovascular mechanical thrombolysis is increasingly favored because of its long therapeutic time window high recanalization rate of large vessel occlusion and other advantages However although mechanical thrombolysis has a high rate of revascularization the clinical prognosis of patients is not satisfactory and both domestic and international studies have found that among patients treated with mechanical thrombolysis the percentage of disability-free at 3 months is less than 30 while the rate of death and disability is as high as more than 70 The ischemia-reperfusion injury that occurs after revascularization may be the root cause of patients still unsatisfactory prognosis Therefore trying to reduce ischemia-reperfusion injury after opening the occluded vessel to further improve the prognosis of patients is a scientific problem that needs to be solved urgently nowadays
At present scholars at home and abroad agree that effective neuroprotective therapy based on revascularization is expected to be an important treatment method to further improve the prognosis of patients with AIS but there is no conclusion on how revascularization should be combined with neuroprotective therapy moreover although a large number of studies have been carried out on neuroprotective therapy for acute ischemic stroke and hundreds of measures have been confirmed to have neuroprotective effects by animal experiments the neuroprotective effects of such measures are not yet known In addition although a large number of studies have been conducted on neuroprotective therapy for acute ischemic stroke and hundreds of measures have been demonstrated to be neuroprotective by animal experiments there are still no clinically available neuroprotective measures
Post-ischemic adaptation is a physical brain protective treatment strategy in which an ischemic event in an organ or tissue is treated and blood flow is restored and an ischemic stimulus is given to local tissues to induce the production of anti-ischemic damage factors and reduce the damage associated with reperfusion therapy This method has been widely studied in the field of coronary heart disease rescue and the results suggest that in situ ischemic post-adaptation immediately after coronary revascularization can safely and effectively reduce ischemia-reperfusion myocardial injury reduce the size of myocardial infarction and improve clinical prognosis The process of mechanical thrombolysis for acute ischemic stroke is similar to that of emergency recanalization for acute coronary syndromes and relevant basic studies have confirmed that post-ischemic adaptation can reduce infarct volume and promote neurological function recovery in animal models of cerebral infarction Therefore it may be beneficial to the recovery of neurological function in patients with acute ischemic stroke undergoing mechanical thrombus extraction
Based on the above background the use of a balloon to repeatedly dilate-contract at the original occlusion site after revascularization to block and restore arterial flow may be an effective cerebroprotective treatment for patients with large-vessel occlusion who undergo thrombolysis However can this approach be safely used in patients with acute ischemic stroke treated with thrombolysis What is the protocol for the length of time patients can tolerate post-ischemic adaptation The application of this method in the treatment of acute ischemic stroke will be explored in this study
At present scholars at home and abroad agree that effective neuroprotective therapy based on revascularization is expected to be an important treatment method to further improve the prognosis of patients with AIS but there is no conclusion on how revascularization should be combined with neuroprotective therapy moreover although a large number of studies have been carried out on neuroprotective therapy for acute ischemic stroke and hundreds of measures have been confirmed to have neuroprotective effects by animal experiments the neuroprotective effects of such measures are not yet known In addition although a large number of studies have been conducted on neuroprotective therapy for acute ischemic stroke and hundreds of measures have been demonstrated to be neuroprotective by animal experiments there are still no clinically available neuroprotective measures
Post-ischemic adaptation is a physical brain protective treatment strategy in which an ischemic event in an organ or tissue is treated and blood flow is restored and an ischemic stimulus is given to local tissues to induce the production of anti-ischemic damage factors and reduce the damage associated with reperfusion therapy This method has been widely studied in the field of coronary heart disease rescue and the results suggest that in situ ischemic post-adaptation immediately after coronary revascularization can safely and effectively reduce ischemia-reperfusion myocardial injury reduce the size of myocardial infarction and improve clinical prognosis The process of mechanical thrombolysis for acute ischemic stroke is similar to that of emergency recanalization for acute coronary syndromes and relevant basic studies have confirmed that post-ischemic adaptation can reduce infarct volume and promote neurological function recovery in animal models of cerebral infarction Therefore it may be beneficial to the recovery of neurological function in patients with acute ischemic stroke undergoing mechanical thrombus extraction
Based on the above background the use of a balloon to repeatedly dilate-contract at the original occlusion site after revascularization to block and restore arterial flow may be an effective cerebroprotective treatment for patients with large-vessel occlusion who undergo thrombolysis However can this approach be safely used in patients with acute ischemic stroke treated with thrombolysis What is the protocol for the length of time patients can tolerate post-ischemic adaptation The application of this method in the treatment of acute ischemic stroke will be explored in this study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
True
Is an FDA AA801 Violation?:
None