Ignite Creation Date:
2024-06-16 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06456476
Status:
RECRUITING
Last Update Posted:
2024-06-13
First Post:
2024-05-27
Brief Title:
Patients With Obstructive Jaundice In Sohag University Hospital
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Study Of Patients With Obstructive Jaundice In Sohag University Hospital
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Jaundice
Brief Summary:
Study of patients with obstructive jaundice in Sohag university hospital study the clinical laboratory and imaging charachteristics in patients with obstructive jaundice admitted to sohag university hospital and to study the available therapeutic options which meight improve patients quality of life and increase survival rates
Detailed Description:
Jaundice is always a pathological sign on most occasions so that it should never be ignored It includes 3 types haemolytic hepatocellular and cholestatic obstructive
Cholestatic jaundice can be classified into two broad categories intrahepatic and extrahepatic Intrahepatic cholestatic jaundice is due to impaired hepatobiliary production and excretion of bile causing bile components to enter the circulation The concentration of conjugated bilirubin in serum is elevated in cholestatic jaundice Intrahepatic cholestasis may be due to primary biliary cirrhosis hepatocellular disease such as acute viral hepatitis infection drug-induced liver injury Dubin-Johnson syndrome Rotor syndrome or cholestatic disease of pregnancy Wilsons disease may also lead to intrahepatic cholestasis due to copper deposition into liver parenchyma with further hepatocellular dysfunction and jaundice1 Extrahepatic cholestasis may be the result of benign causes including choledocholithiasis is the most frequent cause primary sclerosing cholangitis Mirrizi syndrome postoperative billiary stricture post inflammatory stricture pancreatitis choledochal cyst pyogenic cholangitis parasitic diseases duodenal diverticulosis and AIDS cholangiopathy2 While malignant causes include cancer head of pancreas carcinoma of the gall bladder cholangiocarcinoma carcinoma of the duodenum ampullary tumors hepatocellular carcinoma lymphoma and metastatic tumors3 Todays obstructive jaundice is more of a medical entity since gastroenterologists rather than surgeons handle the majority of obstructive jaundice cases with ERCP or stenting4 Obstructive jaundice patients typically complain of jaundice yellowish discoloration of skin and eyes pruritus clay colored stool dark-colored urine and aneroxia5 Jaundice in choledocholithiasis is intermittent and associated with pain6-7 Malignant jaundice commonly presents with persistent and progressive painless jaundice often accompanied by weight loss anemia and abdominal mass6-8 Patients with obstructive jaundice are susceptible to developing deficiencies in nutrition infectious complications acute renal failure and compromised cardiovascular function Other adverse events like endotoxemia hypovolemia and coagulopathy can be subtle and dramatically raise mortality and morbidity9 A combination of many approaches such as the patients history physical examination biochemical tests and imaging are needed Abdominal ultrasonography the first-line imaging modality used for the diagnosis of obstructive jaundice because it is noninvasive fast and widely accessible10 However it is necessary to combine ultrasonography with other imaging techniques such as computed tomography CT endoscopic ultrasonography EUS or magnetic resonance cholangiography MRCP to establish local and distant complications and make a choice of the right therapeutic approach11 also liver biopsy as well as observation of patients course can lead to an accurate diagnosis
Early and precise detection of etiology of obstructive jaundice can help to manage such patients and thus will enhance the patients quality of life and increase the survival rate of patients with malignant pathology12
Cholestatic jaundice can be classified into two broad categories intrahepatic and extrahepatic Intrahepatic cholestatic jaundice is due to impaired hepatobiliary production and excretion of bile causing bile components to enter the circulation The concentration of conjugated bilirubin in serum is elevated in cholestatic jaundice Intrahepatic cholestasis may be due to primary biliary cirrhosis hepatocellular disease such as acute viral hepatitis infection drug-induced liver injury Dubin-Johnson syndrome Rotor syndrome or cholestatic disease of pregnancy Wilsons disease may also lead to intrahepatic cholestasis due to copper deposition into liver parenchyma with further hepatocellular dysfunction and jaundice1 Extrahepatic cholestasis may be the result of benign causes including choledocholithiasis is the most frequent cause primary sclerosing cholangitis Mirrizi syndrome postoperative billiary stricture post inflammatory stricture pancreatitis choledochal cyst pyogenic cholangitis parasitic diseases duodenal diverticulosis and AIDS cholangiopathy2 While malignant causes include cancer head of pancreas carcinoma of the gall bladder cholangiocarcinoma carcinoma of the duodenum ampullary tumors hepatocellular carcinoma lymphoma and metastatic tumors3 Todays obstructive jaundice is more of a medical entity since gastroenterologists rather than surgeons handle the majority of obstructive jaundice cases with ERCP or stenting4 Obstructive jaundice patients typically complain of jaundice yellowish discoloration of skin and eyes pruritus clay colored stool dark-colored urine and aneroxia5 Jaundice in choledocholithiasis is intermittent and associated with pain6-7 Malignant jaundice commonly presents with persistent and progressive painless jaundice often accompanied by weight loss anemia and abdominal mass6-8 Patients with obstructive jaundice are susceptible to developing deficiencies in nutrition infectious complications acute renal failure and compromised cardiovascular function Other adverse events like endotoxemia hypovolemia and coagulopathy can be subtle and dramatically raise mortality and morbidity9 A combination of many approaches such as the patients history physical examination biochemical tests and imaging are needed Abdominal ultrasonography the first-line imaging modality used for the diagnosis of obstructive jaundice because it is noninvasive fast and widely accessible10 However it is necessary to combine ultrasonography with other imaging techniques such as computed tomography CT endoscopic ultrasonography EUS or magnetic resonance cholangiography MRCP to establish local and distant complications and make a choice of the right therapeutic approach11 also liver biopsy as well as observation of patients course can lead to an accurate diagnosis
Early and precise detection of etiology of obstructive jaundice can help to manage such patients and thus will enhance the patients quality of life and increase the survival rate of patients with malignant pathology12
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None