Ignite Creation Date:
2024-06-16 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06452121
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-11
First Post:
2024-06-05
Brief Title:
TyG Index as a Marker to Predict Severity of Coronary Artery Disease
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Triglyceride-glucose Index as a Marker to Predict Severity of Coronary Artery Disease
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Triglyceride glucose TyG index is a novel marker which has been demonstrated to have a high sensitivity and specificity in identifying metabolic syndrome Previous studies have shown that TyG index is associated with carotid atherosclerosis coronary artery calcification and high risk of CVD
This study aims to predict severity of CAD using TyG index and its correlation to coronary angiography findings
This study aims to predict severity of CAD using TyG index and its correlation to coronary angiography findings
Detailed Description:
Coronary artery disease CAD is characterized by vulnerable atherosclerotic plaque which causes coronary stenosis and myocardial ischemia The blockage of the blood vessel caused by the detachment of the endovascular plate leads to an acute CAD attack Without timely intervention this can be life-threatening for the patient Currently coronary angiography CAG is the reference standard for diagnosing CAD with inconclusive evidence to confirm the morbid state Although it assesses the severity of coronary vascular occlusion this technique is invasive and carries inherent risks
Hypertriglyceridemia HTG is a common dyslipidemia and the association of triglyceride TG with CVD risk remains controversial However judging from a credible body of evidence we can conclude that HTG is an independent risk factor of developing glucose metabolism disorders Plasma TG levels are strongly associated with raised glucose levels because of the interactions between fat muscle and function of pancreatic β-cells
Moreover accumulation of TG in the liver may cause fatty liver disease which can increase the risk of type 2 diabetes mellitus T2DM Prospective studies have revealed that plasma TG is an independent risk factor for developing T2DM Additionally it has been demonstrated that lowering TG such as fibrates do can significantly attenuate the process of developing insulin resistance Furthermore it also has been reported that both fasting glucose and TG within the high normal range may predict CVD risk Hence evaluating the joint value of TG and fasting glucose in patients with stable coronary artery disease CAD may be clinically in need
Triglyceride glucose TyG index is a novel marker which has been demonstrated to have a high sensitivity and specificity in identifying metabolic syndrome Previous studies have shown that TyG index is associated with carotid atherosclerosis coronary artery calcification and high risk of CVD
Several studies demonstrated that the TyG index has a positive relevance with type 2 diabetes Insulin resistence subclinical myocardial injuryand acute coronary syndrome ACS A higher TyG index correlates with a greater incidence of major adverse cardiovascular events in patients with diabetes and ACS indicating its potential as an independent predictor for cardiovascular disease prognosis
A recent large-scale prospective study suggested that the TyG index is an independent predictor for the progression of coronary artery calcification especially in individuals without heavy coronary artery calcification at baseline Moreover an increased TyG index has been shown to be independently associated with higher risks of atherosclerotic cardiovascular diseases including myocardial infarction and worse prognosis in patients with ACS irrespective of diabetes mellitus
This study aims to predict severity of CAD using TyG index and its correlation to coronary angiography findings
Hypertriglyceridemia HTG is a common dyslipidemia and the association of triglyceride TG with CVD risk remains controversial However judging from a credible body of evidence we can conclude that HTG is an independent risk factor of developing glucose metabolism disorders Plasma TG levels are strongly associated with raised glucose levels because of the interactions between fat muscle and function of pancreatic β-cells
Moreover accumulation of TG in the liver may cause fatty liver disease which can increase the risk of type 2 diabetes mellitus T2DM Prospective studies have revealed that plasma TG is an independent risk factor for developing T2DM Additionally it has been demonstrated that lowering TG such as fibrates do can significantly attenuate the process of developing insulin resistance Furthermore it also has been reported that both fasting glucose and TG within the high normal range may predict CVD risk Hence evaluating the joint value of TG and fasting glucose in patients with stable coronary artery disease CAD may be clinically in need
Triglyceride glucose TyG index is a novel marker which has been demonstrated to have a high sensitivity and specificity in identifying metabolic syndrome Previous studies have shown that TyG index is associated with carotid atherosclerosis coronary artery calcification and high risk of CVD
Several studies demonstrated that the TyG index has a positive relevance with type 2 diabetes Insulin resistence subclinical myocardial injuryand acute coronary syndrome ACS A higher TyG index correlates with a greater incidence of major adverse cardiovascular events in patients with diabetes and ACS indicating its potential as an independent predictor for cardiovascular disease prognosis
A recent large-scale prospective study suggested that the TyG index is an independent predictor for the progression of coronary artery calcification especially in individuals without heavy coronary artery calcification at baseline Moreover an increased TyG index has been shown to be independently associated with higher risks of atherosclerotic cardiovascular diseases including myocardial infarction and worse prognosis in patients with ACS irrespective of diabetes mellitus
This study aims to predict severity of CAD using TyG index and its correlation to coronary angiography findings
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None