Ignite Creation Date:
2024-06-16 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06457113
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-13
First Post:
2024-06-08
Brief Title:
Emotional Attention Bias Modification and Targeted Memory Reactivation in Alcohol Use Disorder
Sponsor:
Shanghai Mental Health Center
Organization:
Shanghai Mental Health Center
Study Overview
Official Title:
Augmentation of Emotional Attention Bias Modification With Targeted Memory Reactivation for Alcohol Use Disorder AUD
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Through this protocol researchers examine whether Targeted Memory Reactivation TMR a technique used to enhance memory can augment the control of craving levels in patients with Alcohol Use Disorder by enhancing positive emotional attention bias modification
Detailed Description:
This protocol uses TMR during REM sleep to strengthen associative memories generated by emotional attention bias modification EABM an effective treatment for controlling craving levels in patients with Alcohol Use Disorder AUD EABM involves exposure to negative emotional words eg frustrated inferior associated with alcohol-related cues and positive emotional words eg successful confident associated with healthy lifestyle cues The goal is to reduce alcohol-related cue positive emotional attention bias EABs In EABM training alcohol-related cues and healthy activity eg exercising reading playing musical instruments images are always paired with negative words and positive words respectively The TMR group receives the EABM protocol with auditory cue feedback sound S1-Alcohol sound S2-Healthy Life the control group receives the EABM protocol without auditory cue feedback All patients will perform EABM every evening and will be exposed to sounds S1 and S2 during REM sleep with a wireless headband which automatically detects sleep stages Clinical evaluation of the EAB and craving levels of AUD will be conducted before and after with a 2-week follow-up The investigators hypothesize that patients treated with EABM and who are exposed during REM sleep to a sound that had previously been associated with the new negative memory of alcohol and the positive memory of a healthy lifestyle TMR group will have more reduced EAB and craving levels compared to participants exposed to the same but non-associated sound during REM sleep control group
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None