Ignite Creation Date:
2024-06-16 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06450834
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-11
First Post:
2024-05-28
Brief Title:
Ostene in Thoracolumbar Decompression and Fusion Evaluated With VIBE
Sponsor:
University of Maryland Baltimore
Organization:
University of Maryland Baltimore
Study Overview
Official Title:
Prospective Propensity-score Matched Cohort Analysis Evaluating the Use of Ostene Bone Hemostasis Material During Thoracolumbar Decompression Instrumentation and Fusion Using a Validated Intraoperative Bleeding Scale
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Ostene VIBe
Brief Summary:
In spine surgery it is important to try to minimize bleeding In particular spine surgery often involves inserting hardware into bone andor removing bone in the spine Because the bone in the spine contains blood vessels there can often be bleeding from the bone itself that is difficult to stop completely One way to stop bone bleeding is through the use of wax-like materials which plug the bleeding bone and act as a physical barrier to stop bleeding One example is Ostene bone hemostasis material which has the advantage of being water soluble meaning it will dissolve naturally over time The purpose of this study is to evaluate how well Ostene does at decreasing bleeding by using a recognized scale called the validated intraoperative bleeding severity scale abbreviated as VIBe In this study the investigators will record the bleeding severity throughout multiple time points in surgery using this scale and then the investigators will compare the measurements to patients in the past who did not receive Ostene Overall this research will help measure how well Ostene decreases bleeding
Detailed Description:
Patients will be screened prior to surgery for inclusion and exclusion criteria
If eligible patients will be approached in the preoperative area or clinic location to consent or refuse participation in the study
Baseline characteristics will be collected via a combination of patient preoperative survey and manual chart review
Patients will undergo the normal surgical standard of care receiving Ostene intraoperatively as determined appropriate by the attending spine surgeon during the procedure
It is anticipated that Ostene will be used specifically during the bony worklaminectomy phase preceding decompression Of note this material is now considered standard of care by our principal investigator and would be used regardless of study participation
Other hemostatic agents will be used according to the typical standard of care
A trained research coordinator will be present to determine VIBe scores during 6 key surgical phases 1 exposure 2 bony worklaminectomy 3 decompression 4 instrumentation 5 fusion and 6 closure Agreement will be obtained from the operating surgeon
For all phases the maximum VIBe score during each phase will be recorded
Surgical information will be documented from the operative note
Patients will receive the normal standard of care postoperatively including measures of their hemoglobinhematocrit and postoperative drain output
Data on postoperative outcomescomplications will be collected from the electronic medical record
A propensity-score matched cohort analysis will be constructed to compare patients who received Ostene to patients who did not receive Ostene will use data from past study conducted from 2021-April 2023 to construct matched control cohort
There will be no group assignment in this study
There will be no placebo group or randomization
Patient data from a past study will be used as a control comparator
If eligible patients will be approached in the preoperative area or clinic location to consent or refuse participation in the study
Baseline characteristics will be collected via a combination of patient preoperative survey and manual chart review
Patients will undergo the normal surgical standard of care receiving Ostene intraoperatively as determined appropriate by the attending spine surgeon during the procedure
It is anticipated that Ostene will be used specifically during the bony worklaminectomy phase preceding decompression Of note this material is now considered standard of care by our principal investigator and would be used regardless of study participation
Other hemostatic agents will be used according to the typical standard of care
A trained research coordinator will be present to determine VIBe scores during 6 key surgical phases 1 exposure 2 bony worklaminectomy 3 decompression 4 instrumentation 5 fusion and 6 closure Agreement will be obtained from the operating surgeon
For all phases the maximum VIBe score during each phase will be recorded
Surgical information will be documented from the operative note
Patients will receive the normal standard of care postoperatively including measures of their hemoglobinhematocrit and postoperative drain output
Data on postoperative outcomescomplications will be collected from the electronic medical record
A propensity-score matched cohort analysis will be constructed to compare patients who received Ostene to patients who did not receive Ostene will use data from past study conducted from 2021-April 2023 to construct matched control cohort
There will be no group assignment in this study
There will be no placebo group or randomization
Patient data from a past study will be used as a control comparator
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
True
Is an FDA AA801 Violation?:
None