Ignite Creation Date:
2024-06-16 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06454162
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-12
First Post:
2024-06-06
Brief Title:
Effect of Adding Modified Ketogenic Diet to Exercise Program in Treating Obese Patient With Multiple Sclerosis A Randomized Controlled Trial
Sponsor:
Cairo University
Organization:
Cairo University
Study Overview
Official Title:
Effect of Adding Modified Ketogenic Diet to Exercise Program in Treating Obese Patient With Multiple Sclerosis A Randomized Controlled Trial
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MS
Brief Summary:
this study will be conducted to investigate the effect of adding Modified Ketogenic diet to exercise program in treating obese patient with multiple sclerosis
Detailed Description:
Multiple sclerosis MS is the most common inflammatory disease of the central nervous system in young adults that may lead to progressive disability Since pharmacological treatments may have substantial side effects there is a need for complementary treatment options such as specific dietary approaches Ketone bodies that are produced during fasting diets FDs and ketogenic diets KDs are an alternative and presumably more efficient energy source for the brainKetogenic diets KDs are high-fat low-carbohydrate diets that mimic a fasting state KDs create a metabolic shift from glycolytic energy production toward oxidative phosphorylation energetics by using fatty acids as a primary source of energy As these fatty acids undergo beta-oxidation ketones are produced This increase in oxidative phosphorylation coupled with ketone production modifies the tri carboxylic acid cycle to limit reactive oxygen species generation In addition ketone bodies transported across the blood-brain barrier up regulate antioxidant pathway genes particularly via the Nrf2 pathway and boost energy production in brain tissuesixty-four subjects with MS ranged from 18-50 years will be selected randomly divided into two groups each group consists of thirty-two subjects experimental group modified ketogenic diet aerobic exercise and control group aerobic exercise
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None