Ignite Creation Date:
2024-06-16 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06444438
Status:
RECRUITING
Last Update Posted:
2024-06-05
First Post:
2024-05-31
Brief Title:
Radiological Changes of Glymphatic-meningeal Lymphatic Drainage System After Subarachnoid Hemorrhage
Sponsor:
Second Affiliated Hospital School of Medicine Zhejiang University
Organization:
Second Affiliated Hospital School of Medicine Zhejiang University
Study Overview
Official Title:
Radiological Changes of Glymphatic-meningeal Lymphatic Drainage System After Spontaneous Subarachnoid Hemorrhage
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Subarachnoid hemorrhage SAH is a common and extremely critical disease in neurosurgery The mortality rate within 30 days of the onset of SAH is as high as 50 and about 15 of SAH patients die without reaching the hospital Nearly half of the survivors have severe neurological dysfunction causing a huge burden to the families and society of the patients
Recently the introduction of the glymphatic-meningeal lymphatic vessels drainage system has updated the current concept of intracranial cerebrospinal fluid circulation After subarachnoid hemorrhage a large number of blood components flooded into the subarachnoid space and entered the cerebrospinal fluid circulation which directly affected the function of the lymphatic-meningeal lymphatic drainage system Many preclinical animal studies have pointed out that the damage of the lymphatic-meningeal lymphatic drainage system is involved in the aggravation of cerebral edema neuroinflammation and hydrocephalus after SAH which ultimately leads to poor prognosis of patients
However at present the changes of the glymphatic-meningeal lymphatic drainage system after SAH have only been confirmed in animal models and clinical evidence is lacking With the development of imaging technology many research teams have confirmed the functional changes of the lymphatic-meningeal lymphatic drainage system in Alzheimers disease and Parkinsons disease by using different sequences of non-invasive MRI such as 3D T2-FLAIR DTI-ALPS and other sequences
Recently the introduction of the glymphatic-meningeal lymphatic vessels drainage system has updated the current concept of intracranial cerebrospinal fluid circulation After subarachnoid hemorrhage a large number of blood components flooded into the subarachnoid space and entered the cerebrospinal fluid circulation which directly affected the function of the lymphatic-meningeal lymphatic drainage system Many preclinical animal studies have pointed out that the damage of the lymphatic-meningeal lymphatic drainage system is involved in the aggravation of cerebral edema neuroinflammation and hydrocephalus after SAH which ultimately leads to poor prognosis of patients
However at present the changes of the glymphatic-meningeal lymphatic drainage system after SAH have only been confirmed in animal models and clinical evidence is lacking With the development of imaging technology many research teams have confirmed the functional changes of the lymphatic-meningeal lymphatic drainage system in Alzheimers disease and Parkinsons disease by using different sequences of non-invasive MRI such as 3D T2-FLAIR DTI-ALPS and other sequences
Detailed Description:
Subarachnoid hemorrhage SAH is a common and extremely critical disease in neurosurgery The mortality rate within 30 days of the onset of SAH is as high as 50 and about 15 of SAH patients die without reaching the hospital Nearly half of the survivors have severe neurological dysfunction causing a huge burden to the families and society of the patients
Recently the introduction of the glymphatic-meningeal lymphatic vessels drainage system has updated the current concept of intracranial cerebrospinal fluid circulation After subarachnoid hemorrhage a large number of blood components flooded into the subarachnoid space and entered the cerebrospinal fluid circulation which directly affected the function of the lymphatic-meningeal lymphatic drainage system Many preclinical animal studies have pointed out that the damage of the lymphatic-meningeal lymphatic drainage system is involved in the aggravation of cerebral edema neuroinflammation and hydrocephalus after SAH which ultimately leads to poor prognosis of patients
However at present the changes in the glymphatic-meningeal lymphatic drainage system after SAH have only been confirmed in animal models and clinical evidence is lacking With the development of imaging technology many research teams have confirmed the functional changes of the lymphatic-meningeal lymphatic drainage system in Alzheimers disease and Parkinsons disease by using different sequences of non-invasive MRI such as 3D T2-FLAIR DTI-ALPS and other sequences
Recently the introduction of the glymphatic-meningeal lymphatic vessels drainage system has updated the current concept of intracranial cerebrospinal fluid circulation After subarachnoid hemorrhage a large number of blood components flooded into the subarachnoid space and entered the cerebrospinal fluid circulation which directly affected the function of the lymphatic-meningeal lymphatic drainage system Many preclinical animal studies have pointed out that the damage of the lymphatic-meningeal lymphatic drainage system is involved in the aggravation of cerebral edema neuroinflammation and hydrocephalus after SAH which ultimately leads to poor prognosis of patients
However at present the changes in the glymphatic-meningeal lymphatic drainage system after SAH have only been confirmed in animal models and clinical evidence is lacking With the development of imaging technology many research teams have confirmed the functional changes of the lymphatic-meningeal lymphatic drainage system in Alzheimers disease and Parkinsons disease by using different sequences of non-invasive MRI such as 3D T2-FLAIR DTI-ALPS and other sequences
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None