Ignite Creation Date:
2024-06-16 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06449456
Status:
RECRUITING
Last Update Posted:
2024-06-11
First Post:
2024-05-27
Brief Title:
Exercise Capacity Physical Fitness and Physical Activity Levels in Children With CAH
Sponsor:
Hacettepe University
Organization:
Hacettepe University
Study Overview
Official Title:
A Comparison of Exercise Capacity Muscle Functions Physical Fitness and Physical Activity Levels in Children With Congenital Adrenal Hyperplasia and Healthy Controls
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Congenital Adrenal Hyperplesia CAH is a group of automosal recessive disorders that develop due to a deficiency of one of the five enyzmes necessary for cortisol synthesis in the adrenal cortex Research indicates a predisposition in children and adolescents with CAH towards adverse metabolic changes such as obesity hypertension insulin resistance and increased intima-media thickness This study aims to compare the extent to which children and adolescents with CAH are effected in terms of respiratory and peripheral muscle strength exercise capasity physical fitness and physical activity levels compared o their matched healthy individuals
Detailed Description:
Congenital adrenal hyperplasia CAH is a group of autosomal recessive diseases caused by the deficiency of one of the five enzymes necessary for cortisol synthesis in the adrenal cortex Dysfunction in cortisol synthesis as seen in other enzyme deficiencies leads to an increase in adrenocorticotropic hormone ACTH secretion resulting in hypertension and hypokalemia Additionally patients with CAH exhibit excess androgens alongside cortisol deficiency İn CAH treatment glucocorticoids are used to suppress androgen production in the adrenal cortex Deficiency in glucocorticoids and mineralocorticoids as well as excess androgens can contribute to the development of adverse metabolic and cardiovascular anomalies
Ongoing research has revealed a predisposition for adverse metabolic changes in children and adolescents with CAH including obesity hypertension insulin resistance and increased intima-media thickness which can increase the risk of developing cardiovascular disease in adulthood Furthermore subclinical left ventricular diastolic dysfunction has been observed in adolescents with CAH İn these patients due to the deficiency of epinephrine there is an increased tendency for hypoglycemia under stress conditions
These metabolic changes can lead to impaired exercise performance in patients with CAH consequently affecting their quality of life
A study involving twenty classic CAH adolescents and twenty healthy counterparts demonstrated that classic CAH patients exhibited reduced exercise capacity with lower peak workload and higher peak systolic blood pressure during exercise However there is a lack of research in the literature comparing respiratory and peripheral muscle strength daily life activities physical fitness and levels of physical activity in children and adolescents with CAH to their healthy peers
Ongoing research has revealed a predisposition for adverse metabolic changes in children and adolescents with CAH including obesity hypertension insulin resistance and increased intima-media thickness which can increase the risk of developing cardiovascular disease in adulthood Furthermore subclinical left ventricular diastolic dysfunction has been observed in adolescents with CAH İn these patients due to the deficiency of epinephrine there is an increased tendency for hypoglycemia under stress conditions
These metabolic changes can lead to impaired exercise performance in patients with CAH consequently affecting their quality of life
A study involving twenty classic CAH adolescents and twenty healthy counterparts demonstrated that classic CAH patients exhibited reduced exercise capacity with lower peak workload and higher peak systolic blood pressure during exercise However there is a lack of research in the literature comparing respiratory and peripheral muscle strength daily life activities physical fitness and levels of physical activity in children and adolescents with CAH to their healthy peers
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None