Ignite Creation Date:
2024-06-16 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06448975
Status:
RECRUITING
Last Update Posted:
2024-07-12
First Post:
2024-06-03
Brief Title:
An Exploratory Study of Deep Cervical Lymphovenous Bypass LVB in Alzheimers Disease
Sponsor:
Affiliated Hospital of Jiangnan University
Organization:
Affiliated Hospital of Jiangnan University
Study Overview
Official Title:
An Exploratory Study of Deep Cervical Lymphovenous Bypass LVB in Alzheimers Disease
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The main pathological mechanism of Alzheimers Disease AD is the abnormal deposition of amyloid-beta Aβ and tau proteins in the brain Recent studies indicate that these two proteins are primarily cleared through the glymphatic system-meningeal lymphatic vessels-deep cervical lymphatic vessels pathway Lymphatic circulation disorders in elderly patients can directly lead to the abnormal deposition of these proteins Deep cervical lymphovenous bypass can improve lymphatic circulation and effectively treat lymphedema This project aims to verify the effectiveness of deep cervical lymphovenous bypass in treating AD offering a new surgical treatment method to improve cognitive impairment and the quality of life for AD patients
Detailed Description:
Alzheimers Disease AD is a progressive neurodegenerative disorder that insidiously begins Clinically characterized by memory impairment aphasia apraxia agnosia and other symptoms it poses a severe threat to the quality of life of the elderly and brings a heavy burden to society and families To date there are no effective methods to prevent halt or cure AD Therefore there is an urgent need to explore new treatment approaches
The definition of the glymphatic system and the discovery of meningeal lymphatic vessels MLV have overturned the traditional view of the immune privilege of the central nervous system offering new clues and hope for the study and treatment of many brain diseases including AD The main pathological mechanism of Alzheimers Disease AD is the abnormal deposition of amyloid-beta Aβ and tau proteins in the brain Recent research indicates that these two proteins are primarily cleared through the glymphatic system-meningeal lymphatic vessels-deep cervical lymphatic vessels pathway and lymphatic circulation disorders in elderly patients can directly lead to the abnormal deposition of these proteins Deep cervical lymphovenous bypass can improve lymphatic circulation and effectively treat lymphedema This project aims to verify the effectiveness of deep cervical lymphovenous bypass in treating AD providing a new surgical method to improve cognitive impairment and the quality of life for AD patients
The definition of the glymphatic system and the discovery of meningeal lymphatic vessels MLV have overturned the traditional view of the immune privilege of the central nervous system offering new clues and hope for the study and treatment of many brain diseases including AD The main pathological mechanism of Alzheimers Disease AD is the abnormal deposition of amyloid-beta Aβ and tau proteins in the brain Recent research indicates that these two proteins are primarily cleared through the glymphatic system-meningeal lymphatic vessels-deep cervical lymphatic vessels pathway and lymphatic circulation disorders in elderly patients can directly lead to the abnormal deposition of these proteins Deep cervical lymphovenous bypass can improve lymphatic circulation and effectively treat lymphedema This project aims to verify the effectiveness of deep cervical lymphovenous bypass in treating AD providing a new surgical method to improve cognitive impairment and the quality of life for AD patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None