Ignite Creation Date:
2024-06-16 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06445166
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-06
First Post:
2024-05-31
Brief Title:
Propranolol for the Treatment of Kaposi Sarcoma in Adults
Sponsor:
Washington University School of Medicine
Organization:
Washington University School of Medicine
Study Overview
Official Title:
A Multicenter Phase II Study of Propranolol for the Treatment of Kaposi Sarcoma in Adults
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Kaposi sarcoma KS lesions are initiated by endothelial cells infected with KS herpesvirus KSHV also known as human herpesvirus 8 HHV-8 Lesion progression is driven by abnormal angiogenesis chronic inflammation and uncontrolled cell proliferation KS remains one of the most commonly diagnosed cancers in many African countries where economic constraints prevent successful treatment in most patients Treatment outcomes in developed countries are also often unsatisfactory in HIV positive patients despite good virological and immunological responses to antiretroviral therapy Therefore identification of new oral safe treatment options for treatment of KS remains a research priority Given the known anti-angiogenic properties and based on the treatment response with other benign vascular lesions such as infantile hemangioma propranolol is a good candidate for the treatment of KS The hypothesis of this study is that treating patients with Kaposi sarcoma with propranolol will result in an overall response rate complete response rate plus partial response rate of at least 45 and that propranolol will be safe and well tolerated in this patient population
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None