Ignite Creation Date:
2024-06-16 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06443567
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-05
First Post:
2024-05-30
Brief Title:
Arterial Blood Pressure and Cardiac Arrest
Sponsor:
Manchester University NHS Foundation Trust
Organization:
Manchester University NHS Foundation Trust
Study Overview
Official Title:
Arterial Blood Pressure and Cardiac Arrest
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ABaCAS
Brief Summary:
To describe and measure diastolic and systolic femoral arterial pressure during medical cardiac arrest
To define baseline measures To describe and measure arterial blood pressure after placement of an ITD device
To observe the diastolic pressure immediately prior to return of spontaneous circulation
To quantify and describe the effects of intravenous adrenaline on arterial blood pressure in cardiac arrest
To define baseline measures To describe and measure arterial blood pressure after placement of an ITD device
To observe the diastolic pressure immediately prior to return of spontaneous circulation
To quantify and describe the effects of intravenous adrenaline on arterial blood pressure in cardiac arrest
Detailed Description:
Cardiac arrest is a complex disorder whose outcome is reliant on a huge number of factors Moreover many interventions are time critical therefore an intervention that may be lifesaving if given early may have no benefit if instigated further in the disease course For these reasons studies involving cardiac arrest are incredibly difficult to carry out and interpret Many of the interventions carried out during cardiac arrest are aimed at improving blood pressure and thereby increasing the amount of blood and oxygen delivered to the myocardium in the hopes of achieving a return of spontaneous circulation ROSC However current data on what a normal blood pressure based largely upon non-invasive measurement during cardiac arrest is severely limited making comparison and evaluation of interventions extremely difficult This provides the basis for this study in order to prospectively collate and describe data from invasive blood pressure monitoring during adult medical cardiac arrest in the pre-hospital environment
3 Research QuestionAims To measure and describe femoral arterial pressure during cardiac arrest with mechanical CPR by a LUCAS device 31 Objectives Primary objective To quantify and describe baseline arterial systolic blood pressure as measured by an invasive femoral line in adult patients suffering medical cardiac arrest in the pre-hospital setting This will be defined as a line of best fit for systolic blood pressure superimposed on the arterial trace during a 3 minute period
Secondary Objectives
To quantify and describe baseline arterial diastolic blood pressure as measured by an invasive femoral line in adult patients suffering medical cardiac arrest in the pre-hospital setting This will be defined as a line of best fit for diastolic blood pressure superimposed on the arterial trace during a 3 minute period
To quantify and describe arterial blood pressure after the placement of an ITD device over a 3 minute period
To quantify and describe the effect of intravenous adrenaline on blood pressure as administered in line with ALS guidelines every 3-5 mins in adult patients in cardiac arrest
To document the diastolic blood pressure of those patients that achieve return of spontaneous circulation ROSC following out of hospital cardiac arrest
3 Research QuestionAims To measure and describe femoral arterial pressure during cardiac arrest with mechanical CPR by a LUCAS device 31 Objectives Primary objective To quantify and describe baseline arterial systolic blood pressure as measured by an invasive femoral line in adult patients suffering medical cardiac arrest in the pre-hospital setting This will be defined as a line of best fit for systolic blood pressure superimposed on the arterial trace during a 3 minute period
Secondary Objectives
To quantify and describe baseline arterial diastolic blood pressure as measured by an invasive femoral line in adult patients suffering medical cardiac arrest in the pre-hospital setting This will be defined as a line of best fit for diastolic blood pressure superimposed on the arterial trace during a 3 minute period
To quantify and describe arterial blood pressure after the placement of an ITD device over a 3 minute period
To quantify and describe the effect of intravenous adrenaline on blood pressure as administered in line with ALS guidelines every 3-5 mins in adult patients in cardiac arrest
To document the diastolic blood pressure of those patients that achieve return of spontaneous circulation ROSC following out of hospital cardiac arrest
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None